According to the cancer immunoediting model, the interplay between tumor cells and the host immune system is crucial for the control of tumor growth. NB is a pediatric tumor that presents with metastatic disease at diagnosis in about 50% of the cases, the majority of which have poor prognosis. In this Review article, immune escape pathways adopted by human neuroblastoma (NB) cells are reviewed....

Between 1971 and 1989 measles encephalitis was identified in five children receiving chemotherapy for acute lymphoblastic leukaemia. Review of these and previously reported cases of measles encephalitis in immunosuppressed patients failed to identify any pathognomonic features in the history, the clinical presentation, or the results of electroencephalography or computed tomography. Detection o...

Pemphigus is a chronic blistering mucocutaneous disease, classified in immunobullous skin diseases. Infections, particularly septicemia due to Staphylococcus aureus and Pseudomonas aeroginosa are the most common and dangerous disorders due to immunosuppressive therapy in this disease. Infection with nocardia is rare, so that only 6 cases have been reported yet. Herein, we report a 56-year-old m...

Prostatic carcinoma is the most commonly diagnosed tumor among men over 40 which results in over 30,000 deaths each year in the United States. Previous studies indicated that tumor cell lines produce and release several growth regulatory factors into their condition media and so far a number of human tumor cell-derived suppressor factors have been isolated that affect normal immune functions. I...

The last few decades have witnessed remarkable achievements in the development of immunosuppressive drugs, made possible by significant advances in molecular immunology and improved understanding of the mechanisms by which cells communicate. The identification of the relevant cells involved in a pathological process is the key to understanding effective immunosuppressive strategies. For example...

A vast range of different compounds seem capable of depressing the immune response, however, it has been disappointing that so few of these have shown potential as immunosuppressive agents in man. The action of many has been to suppress lymphocyte reactivity in vitro and of those that are capable of prolonging graft survival in animals in addition, just a handful have been found to be safe and ...