Allogeneic marrow transplantation can cure sickle cell disease; however, HLA-matched donors are difficult to find, and the toxicities of myeloablative conditioning are prohibitive for most adults with this disease. We developed a nonmyeloablative bone marrow transplantation platform using related, including HLA-haploidentical, donors for patients with sickle cell disease. The regimen consisted ...

Solid organ transplantation is the treatment of choice for patients with end-stage organ dysfunction. Despite improvements in short-term outcome, long-term outcome is suboptimal due to the increased morbidity and mortality associated with the toxicity of immunosuppressive regimens and chronic rejection (1-5). As such, the attention of the transplant community has focused on the development of n...

BACKGROUND AND OBJECTIVES Until the end of the previous century it remained controversial to admit cancer patients to the ICU for advanced-life-supporting therapy. However, over the past few years several centres over the world have shown that it is possible to achieve a meaningful survival in these patients. The aim of this review is to focus on the improvement in outcome that has been achieve...

The generation of induced pluripotent stem cells (iPSCs), especially the generation of patient-derived pluripotent stem cells (PSCs) suitable for disease modelling in vitro, opens the door for the potential translation of stem-cell related studies into the clinic. Successful replacement, or augmentation, of the function of damaged cells by patientderived differentiated stem cells would provide ...

γδ T cells play a role in a wide range of diseases such as autoimmunity and cancer. The majority of circulating human γδ T lymphocytes express a Vγ9Vδ2+ (Vδ2+) T cell receptor (TCR) and following activation release pro-inflammatory cytokines. In this study, we show that IFNγ, produced by Vδ2+ cells, activates mesenchymal stem cell (MSC)-mediated immunosupression, which in turn exerts a negative...

Allogeneic hematopietic stem cell transplantation (aHSCT) is widely used for the treatment of hematologic malignancies. Although aHSCT provides a good response against the malignant cells (graft-versus-leukemia [GVL]), it also leads to the development of graft-versus-host disease (GVHD), a severe disease with high mortality and morbidity rates. Therapy for GVHD is commonly based on nonspecific ...

Objective: This study assessed the effect of diode laser 808nm low-level laser therapy (LLLT) on oral mucous wound healing for immunosuppressed rabbits under corticosteroid therapy. Material and Methods: Twenty-four adult male New Zealand White rabbits were subjected to Immunosupression via dexamethasone injection, the animals were subjected to equal surgical incisions in oral mucous membrane i...

A 29-year-old woman was admitted with a 2-day history of fever, cough, hemoptysis, abdominal pain, and diarrhea. She had received a renal transplantation 4 months before and was receiving mycophenolate mofetil, tacrolimus, and prednisone. Two days after admission, she developed a petechial rash on the abdomen (Figure 1), paralytic ileus, and progressive respiratory distress requiring mechanical...

BACKGROUND Many cancers are known to be associated with paraneoplastic syndromes. These syndromes are usually treated by chemotherapy with or without immunosupression but they often respond poorly. There are no published reviews on response to endocrine treatment. CASE PRESENTATION We report a case of a patient presenting with papillitis, myositis and sensory peripheral neuropathy 18 months b...