Tricyclic antidepressants such as amitriptyline (AMT) have been reported to have adverse side effects on cardiac performance. AMT effects on Ca handling in ventricular myocytes, however, are not well understood. Therefore, we investigated AMT action on sarcoplasmic reticulum (SR) Ca release in ventricular myocytes, ryanodine receptor (RyR) activity, and Ca uptake by SR microsomes. In permeabili...

Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including pathogenic bacteria during phagocytosis. I find here that nonsynonymous divergence in three class C scavenger receptors (Sr-C's) between Drosophila melanogaster and D. simulans and between each of these species and D. yakuba is approximately four times the typical genome av...

Macrophages express a number of proteins involved in sterol efflux pathways, including apolipoprotein E (apoE) and scavenger receptor class B type I (SR-BI). We have investigated a potential interaction between these two sterol efflux pathways in modulating overall macrophage sterol flux. We utilized an experimental system in which we increased expression of each of these proteins to a high phy...

This paper mainly investigates the phenomenon of stochastic resonance (SR) in a bistable system subjected to Poisson white noise. Statistical complexity measures, as new tools, are first employed to quantify SR phenomenon of given systemwith Poissonwhite noise. To begin with, the effect of Poisson white noise on SR phenomenon is studied. The results demonstrate that the curves of statistical co...

During gram-negative bacterial infections, lipopolysaccharide (LPS) stimulates primed macrophages (Mphi) to release inflammatory mediators such as tumor necrosis factor (TNF)-alpha, which can cause hypotension, organ failure, and often death. Several different receptors on Mphi have been shown to bind LPS, including the type A scavenger receptor (SR-A). This receptor is able to bind a broad ran...

PURPOSE A discrete subpopulation of steroid refractory (SR) CD4(+) T cells has recently been identified in patients with SR ulcerative colitis (UC). The purpose of this study was to test whether this subpopulation is also present in patients with clinically defined SR uveitis. As interleukin (IL)-2 experimentally mediates the SR phenotype, the combined effects of dexamethasone (Dex) and a range...

Preliminary results of experiments on D2 gas permeation using a system [vacuum/CaO/Sr/PdD x/D2] have shown some evidence of nuclear transmutation from Sr to Mo. The system is a little simpler than that used by Iwamura et al., and has a reversed gas flow direction. The diagnostic method used to identify the elements was conventional XPS, giving the areal densities of 4.21014 cm-2 (Sr) and 3.31...

A long wiggler section is required in each ILC damping ring to provide short radiation damping times. Synchrotron radiation (SR) generated by the beam in the wigglers must be absorbed by different components of the vacuum vessel, including specially designed absorbers. The optimisation of the mechanical design, vacuum system and electron cloud mitigation requires accurate calculation of the SR ...

Most regulatory pathways are governed by the reversible phosphorylation of proteins. Recent developments in mass spectrometry-based technology allow the large-scale analysis of protein phosphorylation. Here, we show the application of immobilized metal affinity chromatography to purify phosphopeptides from Arabidopsis extracts. Phosphopeptide sequences were identified by liquid chromatography-t...

Background (Ba,Sr)SO4 solid-solutions range among the most important scaling minerals, not only in geothermal energy production, but generally in applications involving hydrothermal brines, e.g. including petroleum production [e.g. (Todd and Yuan 1990, 1992; Kühn et al. 1997)]. Besides the general difficulties related to scale formation, like blockage of pipes, related decrease of well producti...