d-Amphetamine selectively promotes release of both dopamine (DA) and norepinephrine (NE) versus serotonin (5HT), and chronic d-amphetamine treatment decreases cocaine-taking behavior in rats, nonhuman primates, and humans. However, abuse liability limits the clinical utility of amphetamine maintenance for treating cocaine abuse. One strategy to improve safety and efficacy of monoamine releasers...

A series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor antimicrobial agents. The structures the prepared compounds evaluated based on elemental analysis, IR, 1H- 13NMR, well MS spectra. X-ray crystal analysis representative 2l showed that acrylonitrile double bond was Z-configured. All screened at National Cancer Inst...

3-Substituted (indol-2-yl)-α-allenols show divergent patterns of reactivity under metal catalysis. An unprecedented intramolecular 1,3-iodine migration is described.

Alkynes generally serve as C2 synthons in transition-metal-catalyzed C−H annulations, herein, exploiting electron-deficient alkynes unconventional C1 synthons, the chemo- and regiospecific synthesis of functionalized 1H-imidazo[1,5-a]indol-3(2H)-ones via a redox-neutral rhodium(III)-catalyzed [4+1] annulation N-carbamoyl indoles has been achieved. This process is characterized by high regiosele...

The title compound, C19H20N2O·C2H5OH, is an ethanol solvate of an indol alkaloid which was extracted from the plant Vinca erecta. The fused piperidine ring adopts an approximate boat conformation and the pyrrolidine ring an envelope conformation with one of the methyl-ene C atoms at the flap. An intra-molecular N-H⋯O hydrogen bond forms an S6 ring motif. In the crystal, norfulorocurarine and et...

A series of novel N-((2,5-diaryl-3-trifluoroacetyl)-1H-indol-7-yl)acetamides has been prepared via a successive and one-pot reaction sequence involving initial trifluoroacetic acid-mediated Beckmann rearrangement of the oximes derived from the 1-(2,5-diaryl-1H-indol-7-yl)ethanones, followed by trifluoroacetylation of the incipient N-(2,5-diaryl-1H-indol-7-yl)-acetamides with trifluoroacetic anh...

Orkidelerde polenler polinaryum denen kümeler şeklindedir ve orkide polinaryumlarında hormonal hiçbir çalışmaya rastlanmamıştır. Bu nedenle çalışmanın amacı polinaryumlarındaki hormonların tespit edilmesidir. amaçla araziden toplanan Ophrys mammosa subsp polinaryumları, laboratuvara getirilmiştir. Çalışmada Salisilik asit(SA), Absisik asit(ABA), Jasmonik asit(JA), Gibberellik asit(GA3) Indol-3-...