نتایج جستجو برای: indoleamine 2
تعداد نتایج: 2526824 فیلتر نتایج به سال:
Abstract: Intracellular tryptophan (Trp) is catabolized to a large repertoire of metabolites via two major pathways: indoleamine and 2, 3-dioxygenases (IDO/TDO) Trp hydroxylase (TPH) pathways. The catabolites possess diverse biological activities carry out various physiological functions. Several such as kynurenine (Kyn) serotonin promote while melatonin 5-methoxytryptophan (5-MTP) suppress can...
Purpose: Cyclooxygenase-2 (COX-2) and its metabolite, PGE2 affect multiple tumorigenesis, including angiogenesis, invasion, and tumor-induced immune suppression. Their overexpression is association with impaired immune cell function in many tumors. Indoleamine 2,3-dioxygenase (IDO) is an emerging immuno-regulatory enzyme that can catalyze the initial rate-limiting step in tryptophan catabolism,...
Melatonin is an indoleamine derivative synthesised mainly in the pineal gland. Its association with periodontal disease and treatment exogenous supplementation of via oral route, topical application as local drug delivery has been documented evidences literature. This review article focuses on melatonin functions periodontium which includes its anti-inflammatory, antioxidant, antiresorptive imm...
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