BACKGROUND Dyspnea may be a presenting symptom of type I food hypersensitivity; bronchial hyperactivity, without known asthma, can coexist in patients with food allergy. OBJECTIVE To evaluate airway involvement in young adult patients with food allergy and no asthma and compare the findings to those of patients with food allergy and asthma, with food allergy and allergic rhinitis, with asthma...

Subcutaneous immunotherapy (SCIT) is a classic form of allergen-specific that used to treat birch pollen induced allergic asthma. To investigate the underlying molecular mechanisms SCIT, we aimed profile lung samples explore changes in differential proteome before and after SCIT mice with Fresh lungs were collected from three groups female BALB/c mice: 1) control mice, 2) pollen-induced 3) SCIT...

Allergic asthma and rhinitis are two common chronic allergic diseases that affect the lungs and nose, respectively. Both diseases share clinical and pathological features characteristic of excessive allergen-induced type 2 inflammation, orchestrated by memory CD4(+) T cells that produce type 2 cytokines (Th2 cells). However, a large majority of subjects with allergic rhinitis do not develop ast...

The active metabolite of vitamin D (1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))) is known to modulate the immune response in Th1 cell-directed diseases. To investigate the role of vitamin D in Th2 cell-directed diseases, experimental allergic asthma was induced in vitamin D receptor (VDR) knockout and in wild-type (WT) mice. As expected, WT mice developed symptoms of airway inflammation with a...

Allergic asthma is characterized by chronic airway inflammation and hyperreactivity and is thought to be mediated by an adaptive T helper-2 (Th2) cell-type immune response. Here, we demonstrate that type 2 pulmonary innate lymphoid cells (ILC2s) significantly contribute to production of the key cytokines IL-5 and IL-13 in experimental asthma. In naive mice, lineage-marker negative ILC2s express...

Asthma is a chronic respiratory disorder in which immunological and structural cells play role. The limits of conventional medicines necessitate the development innovative therapeutic techniques for asthma. In present study, we investigated possible protective effect cinnamic acid (CA) on ovalbumin-induced asthma mouse model. Sixty albino male mice BALB/c type weighing (20-30) grams were chosen...

Airway remodeling due to increased airway smooth muscle (ASM) mass, likely due to enhanced migration and proliferation, has been shown to be highly associated with decline in lung function in asthma. Thymic stromal lymphopoietin (TSLP) is an IL-7-like, pro-allergic cytokine that has been shown to be necessary and sufficient for the development of allergic asthma. Human ASM (HASM) cells express ...

Occupational asthma can be induced by a variety of agents, including high and low molecular weight sensitisers, and respiratory irritants [1]. The role of exposure to cleaning products and disinfectants in work-related asthma is increasingly recognised, although the specific substances that increase asthma risk are not well identified [2]. Some of the numerous agents contained in these products...