نتایج جستجو برای: inflammatory cns disease
تعداد نتایج: 1726768 فیلتر نتایج به سال:
Microglia is the effector cell of the innate immune system in central nervous system (CNS). These cells mediate inflammatory responses in injuries. Besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. Mechanisms of epigenetic regulation mainly consist of DNA methylation, histone modifications and use of non-coding RNAs. Recent s...
Neurodegenerative disorders encompass a range of conditions affecting the central nervous system (CNS) in which alterations neuronal structure and cellular dysfunction lead to progressive deterioration. Activation microglia expression inflammatory cytokine interleukin-1 (IL-1) CNS have become almost synonymous with neuroinflammation. Additionally, relentless activation IL-1 signalling pathway h...
systemic amyloidosis is a very rare complication of inflammatory bowel disease (ibd). the reported cases of secondary amyloidosis in children with ibd are much fewer than those reported in adults. herein, a teenage boy with crohn’s disease is presented who developed nephrotic syndrome due to renal involvement secondary to amyloidosis, whereas the patient was under treatment with corticosteroid ...
abstract background and purpose: customer quality (cq) refers to knowledge, attitude, and skills of service-user in treatment process and this study aims to assess it in delivered care to patients with inflammatory bowel disease (ibd) in tabriz city, iran, 2012. materials and methods: this is a cross-sectional investigation in which the target population includes 94 patients with ibd, who had m...
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients. Autoreactive T cells are important drivers of the disease; however, the efficacy of B cell depleting therapies uncovered an essential role for B cells in disease pathogenesis. They can contr...
ascites in the course of crohn's diseases is rare and is usually a sign of a concomitant malignancy, infection or thrombosis of portal or hepatic vein. herein, we reported on a 26-year-old man who was initially admitted with severe crohn's ileocolitis complicated by copious exudative ascites, abdominal pain and sever diarrhea. in our patient, we could not find any of the aforementioned conditio...
Multiple sclerosis is a chronic demyelinating inflammatory disease of the central nervous system (CNS). As the tissue macrophage of the CNS, microglia have the potential to regulate and be regulated by cells of the CNS and by CNS-infiltrating immune cells. The exquisite sensitivity of microglia to these signals, coupled with their ability to develop a broad range of effector functions, allows t...
RATIONALE Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous system (CNS). The function of platelets in inflammatory and autoimmune pathologies is thus far poorly defined. OBJECTIVE We addressed the role of platelets in mediating CNS inflammation in EAE. METHODS AND RESULTS We found that platelets w...
Cryptococcus neoformans is a major fungal pathogen that disseminates to the central nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune responses within this immune-privileged site. CD4+ T cells have demonstrated roles in anticryptococcal defenses, but increasing evidence suggests that they may contribute to clinical deterioration and pathology in both HIV-...
purpose: risk factors of pelvic inflammatory disease can be different in different countries because of different sexual behaviors and religious restrictions. this study investigated the risk factors of this disease in iranian women in tehran. materials and methods: in this cross-sectional, descriptive study 1104 women with pelvic inflammatory disease were assessed from may 2010 to march 2011. ...
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