In the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in Parkinsonian rats was studied using the microdialysis technique. Our results showed significant differences (p

Drug Delivery In article number 2207787, Can Yang Zhang, Wei Tao, and co-workers review the recent advances in living-leukocyte-mediated drug delivery. Due to targeted response inflammatory environment, leukocytes (e.g., neutrophils, macrophages, lymphocytes) have great potential as carriers for delivery are expected bring breakthroughs precise treatment of cancer inflammation-related diseases.

In the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in Parkinsonian rats was studied using the microdialysis technique. Our results showed significant differences (p

Drug molecules not only interact with specific targets, but also alter the state and function of the associated biological network. How to design drugs and evaluate their functions at the systems level becomes a key issue in highly efficient and low-side-effect drug design. The arachidonic acid metabolic network is the network that produces inflammatory mediators, in which several enzymes, incl...

Clinical effect of TESSYS technique under spinal endoscopy combined with drug therapy in patients lumbar disc herniation and its on quality life serum inflammatory factors: results a randomized trial

The combination of oral antidiabetic drugs, pioglitazone, metformin, and glibenclamide, which also exhibit the strongest anti-inflammatory action among were loaded into chitosan/gelatin/polycaprolactone (PCL) by electrospinning polyvinyl pyrrolidone (PVP)/PCL composite nanofibrous scaffolds pressurized gyration to compare diabetic wound healing effect. therapies significantly accelerated in typ...

levamisole is an anthelmintic agent and also immunostimulant drug which is used to treat colorectal cancer. the present study aimed to show accidental consumption of levamisole alone induced multifocal inflammatory leukoencephalopathy. a 53-year-old male was admitted to the neurology department of farabi hospital (kermanshah, iran) with walking inability and recognition disorder. following clin...

fibrates, as hypolipidemic drugs known as agonists of peroxisome proliferator-activated receptors, diminish inflammatory responses. studies have shown that incorporation of a silicon atom into a drug structure improves its pharmacological potency, modifies its selectivity toward a given target, or changes its metabolic rate, in addition to increasing the lipophilicity of the compounds. a silico...

Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are a major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b ...