Outbreak of coronavirus seems to have exacerbated across the globe, but drugs not been discovered till now. Due having antiviral activity D-glucopyranoside derivatives, this study was designed examine as inhibitor by in sillico against main protease (Mpro) and Spike (Spro) SARS-CoV-2. First, these derivatives were optimised Density Functional Theory (DFT). The observation monitored molecular do...

The effect of theta pulse stimulation (TPS) on pentylenetetrazol (PTZ)-induced long-term potentiation of population spikes (PS) was studied in the hippocampal CA1 in vitro. A transient PTZ application produced a long-lasting enhancement of PS amplitude. A 3-min episode of TPS delivered at a higher intensity produced complete reversal of the PTZ potentiation when delivered during the last minute...

The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is mutated or deleted in half of human cancers, demonstrating the crucial role of P53 in tumor suppression. There are reports of nearly 250 independent germ line TP53 mutations in over 100 publications. The P53 protein has the structure of a transcription factor and, is made up of several domains. T...

A general single-step approach is introduced for the green fabrication of hybrid biosensors from water dispersion. The resulting device integrates semiconducting properties a carbon nanotube (CNT) and functionality protein. In initial aqueous phase, protein (viz., lysozyme [LZ]) disperses (6,5)CNT. Drop-casting dispersion on test pattern (a silicon wafer with interdigitated Au source drain elec...

Objective(s): Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects through modulating the function of other systems. This study analyzed the interaction between APJ and kappa OPRs (KOR) in cardiac responsiveness to apelin in acute reno-...