We report an analysis of in vitro and in vivo drug release from an in situ formulation consisting of triamcinolone acetonide (TR) and poly(D,L-lactide-co-glycolide) (PLGA) and the additives glycofurol (GL) and hydroxyapatite nanoparticles (HA). We found that these additives enhanced drug release rate. We used the Taguchi method to predict optimum formulation variables to minimize the initial bu...

Background and objectives: Tribulus terrestris is a flowering herb (Zygophyllaceae) with several properties in folk medicine such as diuretic, tonic, aphrodisiac, analgesic, astringent, and stomachic-lithotripter activities. Although, some extracts and phytochemicals represent excellent bio-activity in vitro, less or no in vivo activity is observed du...

Cellulose propionate (CP) microparticles containing captopril (CAP) were prepared by solvent evaporation technique. The effects of polymer molecular weight, polymer composition and drug:polymer ratios on the particle size, flow properties, morphology, surface properties and release characteristics of the prepared captopril microparticles were examined. The anti-hypertensive effect of the select...

   The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...

abstractthe aim of the present study was to formulate poly (lactide-co-glycolide) (plga) nanoparticles loaded with 18-β-glycyrrhetinic acid (gla) with appropriate physicochemical properties and antimicrobial activity. gla loaded plga nanoparticles were prepared with different drug to polymer ratios, acetone contents and sonication times and the antibacterial activity of the developed nanopartic...

the purpose of this study was to investigate the effect of additives, poly(ethylene glycol) (peg) 1450, poloxamer 407, polyvinyl alcohol (pva) and sodium chloride in order to improve physico-chemical characteristics, encapsulation efficiency and in vitro release of bovine serum albumin, form poly(d,l-lactic-co-glycolic acid) (plga) microparticles prepared by the w/o/w solvent evaporation method...

In this paper we describe a strategy for sustained release of nitrogen into the soil. Specifically, ureamodified hydroxyapatite nanoparticles were encapsulated under pressure into cavities of the soft wood of Gliricidia sepium. Nitrogen release of the nanofertilizer composition was studied using soil from three elevations in Sri Lanka (pH 4.2, 5.2 and 7) and compared with that of a commercial f...

The use of nanoporous anodic alumina (NAA) for the development of drug delivery systems has gained much attention in recent years. The release of drugs loaded inside NAA pores is complex and depends on the morphology of the pores. In this study, NAA, with different three-dimensional (3D) pore structures (cylindrical pores with several pore diameters, multilayered nanofunnels, and multilayered i...

background microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. the microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. acetone/paraffin systems are conventionally used. objectives the current study aimed to investigate two diffe...

a box-behnken design with three replicates was used for preparation and evaluation of eudragit vancomycin (vcm) nanoparticles prepared by double emulsion. the purpose of this work was to optimize vcm nanoparticles to improve the physicochemical properties. nanoparticles were formed by using w1/o/w2 double-emulsion solvent evaporation method using eudragit rs as a retardant material. full factor...