Background Autoimmune inner ear disease (AIED) is a rare entity that presents with sensorineural hearing loss. In the US, incidence rate less than 5 per 100,000 people [1]. The pathophysiology behind thought to be humoral and cell-mediated process damages cochlea [2]. Clinical presentation characterized by fluctuating, asymmetric loss tends progress over time. Half of patients AIED present vest...

BACKGROUND Immune related adverse events affecting various organ systems are a recognized potential consequence of immune checkpoint inhibition. However, autoimmune inner ear disease is one complication not previously associated with the use of checkpoint inhibitors, though it has been reported after adoptive cell immunotherapy. CASE PRESENTATION Here we present what we believe is the first c...

Asthma in the inner city contributes to high morbidity and mortality, and, in school children, reduced school attendance and alteration in academic performance. There is a need to improve asthma care in the inner city by reducing asthma exacerbations. Methods are currently available to predict and prevent seasonal exacerbations of asthma. In addition, new medications are being developed that wi...

Ear pain, also known as earache or otalgia, is pain in the ear. The pain that originates inside the ear is called as Primary ear pain or otogenic otalgia. It can be caused by disease in the inner, middle, or external ear, but the three are difficult to distinguish in terms of the pain experienced [1]. If ear pain arises from pathologies in surrounding structures it is called as secondary or ref...

performing cochlear implantation in patients with inner ear malformation has always been a matter of dispute. this study was designed to analyze the operative findings,complications, and postoperative performance of patients with inner ear anomalies who underwent cochlear implantation. six patients with inner ear malformations underwent implantation in our academic tertiary referral center from...

The homeostasis of inner-ear fluids is essential for the functions of hearing and equilibrium. Inner-ear disorders, such as Ménière's disease, are affected by inner-ear pressure. The displacement of the human tympanic membrane can be studied by means of the MMS-10 Tympanic Displacement Analyser (Marchbanks Measurement Systems Ltd., UK) and is thought to be a measure for perilymphatic pressure v...

1299 www.drugdiscoverytoday.com In recent years there has been increasing interest in the treatment of inner-ear disorders by local rather than systemic application of drugs. Substances are applied intratympanically, which means they are injected into the middle-ear cavity. This procedure is based on the premise that the drug will contact the round window membrane (RWM) of the cochlea, enter th...