We describe a method of audit of a type of total knee replacement, including some details of the organisational difficulties of administering multicentre studies, and draw attention to how this can be done using industrial funding without prejudicing the study. This is a prospective record of 1439 patients who had an Insall-Burstein II (IBII) prosthesis implanted between 1990 and 1994. The data...

High tibial osteotomy (HTO) has traditionally been performed to correct the mechanical axis of the knee in patients with osteoarthritis (OA) of the medial compartment associated with pain and functional impairment; in these patients the restoration of the alignment was related to the regeneration of the articular cartilage that seemed apparently normal (Fujisawa et al., 1979; Odenbring et al., ...

PURPOSE The purpose of this study is to assess the clinical and radiological results of patients who underwent patellar retention or resurfacing for moderate or severe patellar articular defects during total knee arthroplasty and evaluate the clinical efficacy of patellar resurfacing according to the articular defect of the patella. MATERIALS AND METHODS From May 2003 to March 2006, 252 patie...

The Dictyostelium MAP kinase ERK2 is activated by extracellular cAMP in aggregation-competent cells and is required for receptor activation of adenylyl cyclase (Maeda, M., Aubry, L., Insall, R., Gaskins, C., Devreotes, P. N., and Firtel, R. A. (1996) J. Biol. Chem. 271, 3351-3354; Segall, J., Kuspa, A., Shaulsky, G., Ecke, M., Maeda, M., Gaskins, C., Firtel, R., and Loomis, W. (1995) J. Cell Bi...

BACKGROUND Further knee surgery after proximal tibial osteotomies has been reported to have a more difficult surgical exposure due to decreased patellar height after the osteotomy. Although a decrease in patellar height has been reported for closing-wedge proximal tibial osteotomies, it has not been widely verified among opening-wedge procedures. HYPOTHESIS A significant decrease in patellar ...

PURPOSE The purpose of this study was to conduct a prospective outcome analysis of proximal tibial opening wedge osteotomies performed in young and middle-aged patients (aged <55 years) for the treatment of symptomatic medial compartment osteoarthritis of the knee. METHODS A consecutive series of young and middle-aged adults who underwent proximal tibial opening wedge osteotomies for symptoma...