N,N-diethyl-3-methylbenzamide (DEET) has recently been reported to kill cercariae of Schistosoma mansoni in vitro. In addition, it blocked cercarial entry into mouse tail skin. We confirmed these results and compared the efficacy of DEET to a second insect repellent, 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), in preventing S. mansoni infections in mice. Both AI3-37220 and DE...

A 3-year-old atopic boy developed widespread itching eczematous dermatitis involving his trunk and limbs. The child’s mother stated that she had applied insect repellent wipes (VAPE derm herbal wipes®) on the days before the onset of dermatitis. Treatment with oral antihistamines and topical potent corticosteroids achieved resolution of the lesions within 10 days. The child was patch tested wit...

DEET is the most effective insect repellent available and has been widely used for more than half a century. Here, I review what is known about the olfactory and contact mechanisms of DEET repellency. For mosquitoes, DEET has at least two molecular targets: Odorant Receptors (ORs) mediate the effect of DEET at a distance, while unknown chemoreceptors mediate repellency upon contact. Additionall...

Mosquitoes can carry protozoa, viruses, and worm larvae that cause various diseases in humans.Mosquito repellent preparations are widely sold the market form of lotion preparations.However, most formulas mosquito products on contain DEET (N, N-diethylmeta-toluamide) which has side effects such as symptoms hypersensitivity, irritation, urticaria.Male palm flower (Elaeis guineensis Jacq.) is a na...

The interactions between insect repellents and the olfactory system have been widely studied, however relatively little is known about the effects of repellents on the gustatory system of insects. In this study, we show that the gustatory receptor neuron (GRN) located in the medial styloconic sensilla on the maxillary palps of gypsy moth larvae, and known to be sensitive to feeding deterrents, ...

The repellent and contact toxicities of Alpinia officinarum rhizome extract on Lasioderma serricorne adults, and its ability to protect stored wheat flour from L. serricorne adults infestation were investigated. The A. officinarum extract exhibited strong repellent and contact toxicities against L. serricorne adults. The toxicities enhanced significantly with the increasing treatment time and t...

The spread of resistance to pyrethroids in the major Afrotropical malaria vectors Anopheles gambiae s.s. necessitates the development of new strategies to control resistant mosquito populations. To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticide-resistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repell...

Quwenling, an insect repellent product of China derived from extracts of the lemon eucalyptus plant (Eucalyptus maculata citriodon), was evaluated. Laboratory tests compared Quwenling with deet against Anopheles albimanus, An. quadrimaculatus, Aedes aegypti, Ae. albopictus and field tests with Ae. taeniorhynchus. Cloth treated with Quwenling at greater than 2x the dosage of deet was effective a...

Insect vector-borne diseases remain one of the principal causes of human mortality. In addition to conventional measures of insect control, repellents continue to be the mainstay for personal protection. Because of the increasing pyrethroid-resistant mosquito populations, alternative strategies to reconstitute pyrethroid repellency and knock-down effects have been proposed by mixing the repelle...

Emerging vector-borne diseases have become a concern for travelers and nontravelers alike. Although Ebola has dominated recent headlines, tropical arboviruses such as dengue and chikungunya have more quietly reached the United States. Local transmission of chikungunya virus was first documented in the United States in July 2014, and local spread of dengue has occurred in Florida, Texas, and Haw...