stimulatory investigations revealed persistently elevated immunoreactive GH levels. After glucose load, GH was adequately suppressed. It would have been ideal to measure IGF-1 levels but due to nonavailability of this assay here, it could not be done. A similar case of GH insensitivity syndrome was reported earlier(2). GH insensitivity syndrome encompasses a range of etiologies one of which is ...

This review paper highlights important diagnostic and therapeutic concerns for girls with Complete Androgen Insensitivity Syndrome (CAIS). CAIS is an androgen receptor defect disorder associated with vaginal and uterine agenesis in women with a 46,XY karyotype. The major clinical issues surrounding this syndrome include timing of gonadectomy, hormone replacement, vaginal dilation, and attention...

This report refers to a rare case of complete androgen insensitivity syndrome that had presented at the age of 35 years with complaint of abdominal mass, primary amenorrhea and infertility to Jimma University Hospital. A well-developed breast with absence of axillary and pubic hair was seen on examination. There was also an abdominal mass arising from the pelvis occupying the hypogastric and ri...

Disorders of sexual development (DSD) are congenital anomalies due to atypical development of chromosomes, gonads and anatomy. Complete androgen insensitivity syndrome (CAIS), also known as testicular feminization (TF) is a rare DSD disease. The majority of CAIS patients apply to hospital with the complaint of primary amenorrhea or infertility. Given that CAIS patients are all phenotypically fe...

Genetic, gonadal, phenotypic and psychological genderis the basis for gender assignment to an individual. Derangement in genetic makeup, under or over exposure to sex hormones and problems related to sex hormone receptors will lead to abnormal development of the external and internal genitalia. Failure to respond for the endogenous androgen, Androgen Insensitivity Syndrome is one of the common ...

The metabolic syndrome, a constellation of symptoms associated with obesity, dyslipidaemia, insulin insensitivity, deranged glucose metabolism and hypertension has been gaining widespread interest due to its immense clinical relevance. We review the metabolic syndrome in terms of its diagnostic criteria and its relationship with severe mental illnesses and psychotropic medications, and the guid...

The article presents a clinical observation of an extremely rare in gynecological practice androgen insensitivity syndrome (AIS). authors give data on the pathogenesis disease, modern classification and terminology various forms this pathology. phenotypic manifestations results instrumental studies surgical treatment are described. study show possibility diagnosis AIS timely patients with patho...

We present clinical findings and molecular characterization in two patients previously diagnosed as 46,XY female gonadal dysgenesis with germ cell tumour. Both patients showed a female general phenotype with unambiguously female external genitalia and primary amenorrhoea compatible with complete androgen insensitivity syndrome. The first patient, at the age of 31 years, developed a dysgerminoma...

The complete androgen insensitivity syndrome, previously called testicular feminization syndrome, is an X-linked recessive rare disorder. The individual is phenotypically female and genotypically male: a male pseudohermaphrodite. The individuals are reared as girls and the condition is suspected when the individual is evaluated for primary amenorrhea, infertility, or when unilateral/bilateral i...