thus, we will restrict our discussion to the possible physiological relevance of signaling from the endosome. Given the importance of ERKs (and PI3-K) in signaling, 20141 Milan one would predict dramatic effects of the blockade of University of Milan Medical School endocytosis on biological phenotypes. However, in the 20122 Milan few cases where biological end points were measured, The FIRC Ins...

Let ďc be computable reducibility on ceers. We show that for every computably enumerable equivalence relation (or ceer) R with infinitely many equivalence classes, the index sets ti : Ri ďc Ru (with R non-universal), ti : Ri ěc Ru, and ti : Ri ”c Ru are Σ3 complete, whereas in case R has only finitely many equivalence classes, we have that ti : Ri ďc Ru is Π2 complete, and ti : Ri ěc Ru (with R...

We prove that every disjoint NP-pair is polynomial-time, many-one equivalent to the canonical disjoint NP-pair of some propositional proof system. Therefore, the degree structure of the class of disjoint NP-pairs and of all canonical pairs is identical. Secondly, we show that this degree structure is not superficial: Assuming there exist P-inseparable disjoint pairs, there exist intermediate di...