OBJECTIVE African-American (AA) children are hyperinsulinemic and insulin resistant compared with American white (AW) children. Previously, we demonstrated that insulin secretion relative to insulin sensitivity was approximately 75% higher in AA compared with AW children, suggesting that hyperinsulinemia in AA children is not merely a compensatory response to lower insulin sensitivity. The aim ...

Objective(s): This study was aimed to investigate the effect of Berberis integerrima (B. integerrima) extract on insulin sensitivity in high-fructose-fed insulin-resistant rats. Materials and Methods: Experimental rats were randomly divided into two groups: the control group was fed a regular chow diet while other group fed with a high-fructose diet for 8 weeks. After the first six weeks, the a...

Animal studies suggest that insulin action in the brain is involved in the regulation of peripheral insulin sensitivity. Whether this holds true in humans is unknown. Using intranasal application of insulin to the human brain, we studied the impacts of brain insulin action on whole-body insulin sensitivity and the mechanisms involved in this process. Insulin sensitivity was assessed by hyperins...

The interaction between intracellular magnesium level, adiponectin production and insulin sensitivity has been recently suggested in both diabetic patients and their first-degree relatives. The present study aimed to investigate whether magnesium supplements are able to increase plasma adiponectin and affect insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. Seventy...

The interaction between intracellular magnesium level, adiponectin production and insulin sensitivity has been recently suggested in both diabetic patients and their first-degree relatives. The present study aimed to investigate whether magnesium supplements are able to increase plasma adiponectin and af-fect insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. Sevent...

OBJECTIVE Whereas insulin resistance is expressed as reduced glucose uptake in peripheral tissues, the relationship between and brain metabolism remains controversial. Our aim was to examine association of (BGU) during a euglycemic hyperinsulinemic clamp large sample study participants across wide range age sensitivity. RESEARCH DESIGN AND METHODS [18F]-fluorodeoxyglucose positron emission tomo...