To improve our understanding of the limiting factors during repeated sprinting, we manipulated hypoxia severity during an initial set and examined the effects on performance and associated neuro-mechanical alterations during a subsequent set performed in normoxia. On separate days, 13 active males performed eight 5-s sprints (recovery = 25 s) on an instrumented treadmill in either normoxia near...

The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no proven general therapies. Mice lacking the complex I subunit, Ndufs4, develop a fatal progressive encephalopathy resembling Leigh syndrome and die at ≈60 d of age. We previously reported that continuously bre...

The availability of dietary beta-alanine (BA) is the limiting factor in carnosine synthesis within human muscle due to its low intramuscular concentration and substrate affinity. Carnosine can accept hydrogen ions (H+), making it an important buffer against exercise-induced acidosis. Metabolite accumulation rate increases when exercising hypoxic conditions, thus increased could attenuate H+ bui...

Oxidant generation during regular physical exercise training may influence the adaptive responses that have been shown to confer protection against oxidative stress induced by subsequent acute exercise. To examine this, we randomly assigned 32 males to either a normoxic (n=14) or a hypoxic (n=18) group. During the acute phase, subjects in the hypoxic group performed two maximal cycling tests in...

BACKGROUND Hiking at moderate altitude is a popular outdoor activity in seniors. Acute exercise or altitude can diminish balance performance. Thus, the present study examined the combined effects of altitude and walking on static and dynamic balance. METHODS Thirty-six healthy seniors (age: 62 (SD: 4) y; BMI: 25 (5) kg/m(2)) were examined on three days. Firstly, walking velocity was determine...

objective: recent studies suggest that intermittent and prolonged normobaric hyperoxia (ho) results in ischemic tolerance to preventing ischemia brain injury. in this research attempts were made to see the changes in excitatory amio-acid transporter 3 (eaat3), tnf-α levels, and nf-κb activity following prolonged and intermittent nbho preconditioning. materials and methods: rats were divided i...

The purposes of the present study were to investigate if a) shuttle-run sprint training performed in a normobaric hypoxia chamber of limited size (4.75x2.25m) is feasible, in terms of producing the same absolute training load, when compared to training in normoxia, and b) if such training improves the repeated sprint ability (RSA) and the Yo-Yo intermittent recovery (YYIR) test outcome in young...

High-intensity work might not be preserved in chronic obstructive pulmonary disease (COPD) during whole-body exercise due to ventilatory limitations that exceed metabolic limitations, resulting in reduced training adaptations. The purpose of the present study was to address the hyperoxic effect during training and testing in COPD patients with hypoxemia at peak exercise. Six COPD and eight coro...