نتایج جستجو برای: interferon regulatory factor 7 irf7

تعداد نتایج: 1617638  

Journal: :Journal of virology 2012
Clélia Dental Jonathan Florentin Besma Aouar Francoise Gondois-Rey David Durantel Thomas F Baumert Jacques A Nunes Daniel Olive Ivan Hirsch Ruzena Stranska

Plasmacytoid dendritic cells (pDCs) respond to viral infection by production of alpha interferon (IFN-α), proinflammatory cytokines, and cell differentiation. The elimination of hepatitis C virus (HCV) in more than 50% of chronically infected patients by treatment with IFN-α suggests that pDCs can play an important role in the control of HCV infection. pDCs exposed to HCV-infected hepatoma cell...

Journal: :PNAS nexus 2023

Abstract Actin-binding protein Profilin1 is an important regulator of actin cytoskeletal dynamics in cells, and critical for embryonic development higher eukaryotes. The objective the present study was to examine consequence loss-of-function Pfn1 vascular endothelial cells (ECs) vivo. We utilized a mouse model engineered tamoxifen-inducible bi-allelic inactivation gene selectively EC (Pfn1EC-KO...

2016
Miguel Pinilla-Vera Zeyu Xiong Yutong Zhao Jing Zhao Michael P. Donahoe Suchitra Barge William T. Horne Jay K. Kolls Bryan J. McVerry Anastasiya Birukova Robert M. Tighe W. Michael Foster John Hollingsworth Anuradha Ray Rama Mallampalli Prabir Ray Janet S. Lee

Despite recent advances in understanding macrophage activation, little is known regarding how human alveolar macrophages in health calibrate its transcriptional response to canonical TLR4 activation. In this study, we examined the full spectrum of LPS activation and determined whether the transcriptomic profile of human alveolar macrophages is distinguished by a TIR-domain-containing adapter-in...

Journal: :Journal of immunology 2013
Jie Wang Bo Yang Yu Hu Yuhan Zheng Haiyan Zhou Yanming Wang Yonglei Ma Kairui Mao Leilei Yang Guomei Lin Yongyong Ji Xiaodong Wu Bing Sun

Viral infection causes host cells to produce type I IFNs, which play a critical role in viral clearance. IFN regulatory factor (IRF) 7 is the master regulator of type I IFN-dependent immune responses. In this article, we report that N-Myc and STATs interactor (Nmi), a Sendai virus-inducible protein, interacted with IRF7 and inhibited virus-triggered type I IFN production. The overexpression of ...

Journal: :Brain : a journal of neurology 2012
Xun Jin Sung-Hak Kim Hye-Min Jeon Samuel Beck Young-Woo Sohn Jinlong Yin Jun-Kyum Kim Young Chang Lim Jun-Han Lee Se-Hyuk Kim Shin-Hyuk Kang Xumin Pian Min-Suk Song Jong Bae Park Yang-Seok Chae Yong-Gu Chung Seung-Hoon Lee Yun-Jaie Choi Do-Hyun Nam Young Ki Choi Hyunggee Kim

Inflammatory microenvironment signalling plays a crucial role in tumour progression (i.e. cancer cell proliferation, survival, angiogenesis and metastasis) in many types of human malignancies. However, the role of inflammation in brain tumour pathology remains poorly understood. Here, we report that interferon regulatory factor 7 is a crucial regulator of brain tumour progression and heterogene...

Journal: :The Journal of clinical investigation 2017
Mohd Hafeez Faridi Samia Q Khan Wenpu Zhao Ha Won Lee Mehmet M Altintas Kun Zhang Vinay Kumar Andrew R Armstrong Carmelo Carmona-Rivera Jessica M Dorschner Abigail M Schnaith Xiaobo Li Yogita Ghodke-Puranik Erica Moore Monica Purmalek Jorge Irizarry-Caro Tingting Zhang Rachael Day Darren Stoub Victoria Hoffmann Shehryar Jehangir Khaliqdina Prachal Bhargava Ana M Santander Marta Torroella-Kouri Biju Issac David J Cimbaluk Andrew Zloza Rajeev Prabhakar Shashank Deep Meenakshi Jolly Kwi Hye Koh Jonathan S Reichner Elizabeth M Bradshaw JianFeng Chen Luis F Moita Peter S Yuen Wanxia Li Tsai Bhupinder Singh Jochen Reiser Swapan K Nath Timothy B Niewold Roberto I Vazquez-Padron Mariana J Kaplan Vineet Gupta

Genetic variations in the ITGAM gene (encoding CD11b) strongly associate with risk for systemic lupus erythematosus (SLE). Here we have shown that 3 nonsynonymous ITGAM variants that produce defective CD11b associate with elevated levels of type I interferon (IFN-I) in lupus, suggesting a direct link between reduced CD11b activity and the chronically increased inflammatory status in patients. T...

2016
Hsu P Chong Yolande Cordeaux Yorain Sri Ranjan Sylvia Richardson Benoit Liquet Gordon C S Smith David Stephen Charnock-Jones

In humans, the risk of operative first delivery increases linearly with maternal age. We previously hypothesized that prolonged, cyclical, prepregnancy exposure to estrogen and progesterone contributes to uterine aging. Here, we test this hypothesis. Myometrium was obtained from four groups of virgin mice: (i) 10- to 12-week- and 28- to 30-week-old mice; (ii) 10- to 12-week- and 38- to 40-week-...

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