AIMS To determine the prevalence of cells secreting interleukin-4 (IL-4) in the gut mucosa of children with chronic inflammatory bowel disease. METHODS Mononuclear cells were isolated from intestinal biopsy specimens from control children (n = 10) and children with active inflammatory bowel disease (Crohn's disease n = 15, ulcerative colitis n = 9, indeterminate colitis n = 3). Spontaneous IL...

Inflammatory process is at the heart of artificial (artificial) purulent-inflammatory diseases soft tissues (APDST), which may lead to development phlegmon and abscesses site invasion within a three-day period. The study cytokine status rats with APDST allows us evaluate dynamics inflammation markers assess peculiarities pathological course in model inflammation. experiment was carried out on 1...

Interleukin-4 (IL-4) has previously been found to downregulate interleukin-1 (IL-1) production, but to upregulate the production of IL-1 receptor antagonist (IL-1ra) in human monocytes stimulated with lipopolysaccharide (LPS). In the present study we wanted to determine whether the production of IL-1ra in human monocytes and alveolar macrophages (AMs) is regulated differently at the protein and...

introduction: interleukin-2 (il-2) as a t helper type 1 (th1) cytokine has an important role background and objective: interleukin-2 (il-2) as a t helper type 1 (th1) cytokine has an important role in activation, growth and differentiation of several immune cells. moreover il-2 is known as a pro-inflammatory and anti-tumoral cytokine. in addition deysregulation of il-2 in some diseases such as ...

The effect of Sargassum pallidum (brown seaweed) aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with Sargassum pallidum aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against N-methyl-N′-nitro-Nnitrosoguanidine (MNNG)-induced immunity damage and oxidative injury b...

We have established a unique variant cell line, MC/9.IL-4, which continuously proliferates in the presence of interleukin-4 (IL-4). from a murine interleukin-3 (IL-3)-dependent mast cell line, MC/9 (referred t o as MC/9.IL-3). Compared with MC/9.IL-3 cells, MC/9.IL-4 cells are smaller, lack cytoplasmic granules and metachromasia, carry a very small amount of histamine, and express fewer high-af...

Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. Methods: Seventeen newly diagnosed, untre...