A murine cell line (IxN/2b) absolutely dependent upon exogenous IL-7 for continued growth has been obtained that expresses lymphoid precursor and class I MHC antigens and also contains a rearranged mu heavy chain. This cell line has been used to define the binding and structural characteristics of the murine IL-7 receptor using 125I-labeled recombinant murine IL-7. 125I-IL-7 binding to IxN/2b c...

conclusions this study suggests that the il-7 level of chb patients may be related to tfh cells. in chb patients, il-7 possibly increases the level of tfh cells and hbv-specific cellular immune responses and thereby reduces the hbv dna level. background in patients with chronic hepatitis b (chb), the relation of interkeukin-7 (il-7) to either the t follicular helper cells (tfh cells) or to a sp...

The purposes of this study were t o examine the biologic effects of the engagement of the interleukin-7 receptor (IL-7R) with recombinant human interleukin-7 (rhlL-7) in immunophenotypically distinct T-lineage acute lymphoblastic leukemia (ALL) blasts and t o elucidate the biochemical nature of the IL-7R-linked transmembrane signal in rhlL-7responsive T-lineage ALL blast populations. In the abs...