Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine. In normal intestine, KLF4 is predominantly expressed in the differentiated epithelial cells. It has been identified as a tumor suppressor in colorectal cancer. KLF4 knockout mice demonstr...

We investigated the effects of Cu2+-loaded silicate (CLS) on the growth performance, microflora of skin, gill and intestine, and intestinal morphology of crucian carp Carassius auratus. A total of 225 native wild crucian carp, with an average initial body weight of 20 g, were randomly divided into 5 treatment groups using 3 replicate tanks of 15 fish per group. The dietary treatments were (1) b...

liposarcoma of the digestive tract is very rare only a few cases of liposarcoma of the stomach have been reported so far. in this article a 29-year-old woman is presented with a history of long-standing mid-abdominal pain and various treatments for anemia and peptic ulcer disease which did not improve her symptoms until a barium-enema revealed a filling defect in the cecum. under laparotomy a l...

In our experiment, the effects of bee pollen addition in diet on the functional morphology of small intestine in rats were investigated. The microscopic changes in the small intestine after administration of the pollen addition were evaluated. The experimental animals were divided into one control and three experimental groups of ten rats in each group. Feed given to animals in group A containe...

OASIS is a basic leucine zipper transmembrane transcription factor localized in the endoplasmic reticulum (ER) that is cleaved in its transmembrane region in response to ER stress. This novel ER stress transducer has been demonstrated to express in osteoblasts and astrocytes and promote terminal maturation of these cells. Additionally, OASIS is highly expressed in goblet cells of the large inte...

The aim of this study was the description of the morphology and distribution of nerve structure elements in the intestine of the lizard Podarcis hispanica using different histochemical methods; namely acetylcholinesterase (AChE), formol-induced fluorescence for catecholamines (FIF), nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), and immunohistochemistry for vasoactive intesti...

BACKGROUND Our previous studies indicated that heat stress can cause significant damage to the intestinal epithelium and induce differential expression of many genes in rat small intestine. The transcription factors AP-1 and NF-κB, which act as important mediators by binding to specific DNA sequences within gene promoters, regulate the transcription of genes associated with immune regulation, s...

Small intestine plasmacytoid dendritic cells (pDC) are poorly characterized. Here, we demonstrate that intestinal pDC show the characteristic plasma cell-like morphology, and are recognized by antibodies against B220, Ly6c, 120G8, and PDCA-1, markers that are typically expressed by pDC. Furthermore, intestinal pDC carry high levels of CCR9 and are largely absent in the intestine, but not in lun...

BACKGROUND AND OBJECTIVES Ethanol exposure during gestation induces marked aberrations in growth and development of offsprings collectively known as foetal alcohol syndrome (FAS);. However, its effects on the postnatal development of alcohol dehydrogenase (ADH) are not adequately investigated. Therefore, ADH activity in liver and intestine of rats exposed to ethanol during gestation was studied...

background: a known species lutztrema (lutziella) microacetabularae rhode, 1966 is being described for the first time from pakistan. this species is characterized by having body long and slender, oral sucker subterminal, acetabulum smaller than oral sucker lying in anterior third of the body, pharynx small, esophagus promi-nent which become gradually wider and bifurcates in to two rudimentary c...