BACKGROUND Descemet's membrane detachment (DMD) is one of the most serious complications of modern cataract surgery. We present an alternative technique for management of DMD with a review of the literature on current strategies for the treatment of DMD. CASE PRESENTATION A 74-year-old woman developed DMD after phacoemulsification and failed the first descemetopexy with air tamponade. An alte...

PURPOSE First, to determine the influence of drug lipophilicity (using eight beta-blockers) and molecular weight (using 4 kDa and 40 kDa fluoroscein isothiocyanate [FITC]-dextrans) on suprachoroidal delivery to the posterior segment of the eye by using a rabbit ex vivo eye model. Second, to determine whether drug distribution differs between the dosed and undosed side of the eye following supra...

PURPOSE To present a case of total Descemet's membrane detachment (DMD) after trabeculectomy and its surgical management. CASE REPORT A 68-year-old woman presented with large DMD and corneal edema one day after trabeculectomy. Intracameral air injection on day 3 was not effective. Choroidal effusion complicated the clinical picture with Descemet's membrane (DM) touching the lens. Choroidal ta...

BACKGROUND Rabbits are currently not a good model for studying diseases of the corneal endothelium because their corneal endothelial cells (CECs) maintain a high proliferative capacity throughout almost all their life. Addressing this particular feature might allow the use of this species for such a purpose. The aim of this study was to evaluate the corneal endothelial injury after intracameral...

PURPOSE Ocular perforation during lid anesthesia is rarely reported. We describe here a case of inadvertent corneal perforation and traumatic cataract that occurred during lid anesthesia in a procedure for hordeolum removal. METHODS A 33-year-old woman presented with a sudden visual loss of her left eye. She had undergone hordeolum removal the day before at a local clinic. On ophthalmologic e...

Tissue plasminogen activator, a serine protease encoded by the PLAT gene is present in the trabecular meshwork (TM) and other ocular tissues and has been reported to be downregulated by treatment with steroids in vitro. Steroids are known to cause changes in outflow facility of aqueous humor in many species. In the present study, we tested whether overexpression of PLAT can prevent and/or rever...

INTRODUCTION The aim of this paper was to describe the use of r-TPA for fibrin clot dissolution following endophthalmitis. CLINICAL PICTURE A 74-year-old man presented with painful loss of vision following routine uncomplicated cataract surgery. TREATMENT He underwent standard treatment for postoperative endophthalmitis but despite this, developed a dense fibrin clot. He underwent further i...

Purpose To evaluate posterior and anterior segment safety of an intracameral injection of levofloxacin 0.5% ophthalmic solution as prophylaxis for patients undergoing cataract extraction and intraocular lens implantation. Setting This study was conducted at Manila Doctors Hospital, Ermita, Manila, Philippines. Design This was a prospective interventional study. Methods Eyes undergoing sta...

The relationship between the anterior chamber (AC) of the eye and the immune system was studied after intracameral inoculation with the hapten TNP. Injection of syngeneic TNP-modified splenocytes (TNP-Sp) into the AC of Balb/c mice results in suppressed systemic cell-mediated immunity to TNP as determined by the ear swelling assay. This aberrant immune responsiveness following AC injection of T...

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