Dysembryoplastic Neuroepithelial Tumour (DNET) is a rare brain tumour commonly involving the temporal lobe and presenting with intractable seizures. However, neuroregression as feature of DNET uncommon. We report case 12-year-old boy arising from parietal seizures & neuroregression. The child was subjected to neurosurgical resection lesion following which he made full recovery. A review aft...

Encephalocraniocutaneous lipomatosis (ECCL) is a rare neurocutaneous syndrome that affects ectomesodermal tissues (skin, eyes, adipose tissue, and brain). The neurologic manifestations associated with ECCL are various including seizures. However, ECCL patients very rarely develop brain tumors that originate from the neuroepithelium. This is the first described case of ECCL in combination with d...

Programmed cell death pathways have been implicated in the mechanism by which neurons die following brief and prolonged seizures, but the significance of proapoptotic Bcl-2 family proteins in the process remains poorly defined. Expression of the death agonist Bcl-2-interacting mediator of cell death (Bim) is under the control of the forkhead in rhabdomyosarcoma (FKHR) transcription factors. Thi...

OBJECT Intractable epilepsy following successful brain tumor surgery in children may have several underlying causes such as residual tumor, cortical dysplasia, and gliosis. The authors reviewed the cases of children who had previously undergone resection of a brain tumor only to have medically refractory seizures postoperatively. METHODS The authors performed a retrospective case review of 9 ...

There is an uncertainty regarding the time period for seizures onset and the possible role of tissue changes for constituting an epileptogenic focus in intractable seizures following head trauma. MT MRI was performed in 44 individuals (13 controls, and 31 with seizures from 1-10 years following trauma) to assess the severity of tissue damage and its relationship with intractability. The group w...

Primary antiphospholipid syndrome (APS) is an autoimmune disease defined by vascular thrombosis, pregnancy complications, and persistent antiphospholipid antibodies. Neurological manifestations include stroke, seizures, and chorea among others. Seizures are often precipitated by an acute ischemic event, but occasionally, structural abnormalities are absent. We present a 61-year-old man who deve...

OBJECTIVE Treatment of intractable seizures other than spasms is difficult and controversial. There are few studies on efficacy of adrenocorticotropic hormone (ACTH) in treatment of patients with intractable seizure. MATERIALS & METHODS Twenty-five patients with intractable seizure other than spasm including 14 boys and 11 girls with median age of 58 months referred to university clinics of P...