Admission of a patient to an intensive care unit for management of direct consequences of a hematologic or oncologic disease is occasionally necessary. Such problems included exchange transfusion, sepsis, compression of vital structures by malignant tumor, metabolic derangements, leukostasis, post-operative care, major sickling episodes in vital organs, and disseminated coagulopathy. More often...

Concentrations of DL-glyceraldehyde between 5 and 20 mM reduce the sickling of S/S erythrocytes even in the complete absence of oxygen; at 10 mM glyceraldehyde the increase in the number of normal cells ranges from 20 to 40%. The inhibition of sickling was both concentration- and time-dependent and was not reversed by repeated washings with buffer. Incubation of erythrocytes with increasing con...

a 43-year-old man with liver cirrhosis received transjugular intrahepatic portosystemic shunt (tips) for the treatment of recurrent variceal bleeding and f3 esophageal varices. during routine follow up liver ultrasound examination, six months after the implantation, tips occlusion was suspected and tips revision was performed. during the revision, moderate to severe stenosis at the hepatic veno...

Background: Sickle cells are easily identified on the peripheral smear however quantification of sickle is seldom done. This study attempts to understand importance sickling index in reporting patients with SCD. Objectives: aims standardize methodology paediatric SCD cases and its relation patient characteristics like age sex, genotype, treatment. Materials Methods: A prospective 6 months durat...

In Sudan, sickle cell anemia (SCA) is one of the most common inherited disorders hemoglobin that has complications and becomes world problem. Nigella sativa NS (black seed) been reported to have calcium antagonist antioxidant activities, both which play a role in management anemia. The aim current study was evaluate anti-sickling activity extracts, forty patients with were recruited for study. ...

Several screening methods for detecting sickling hemoglobins are presently used in the clinical laboratory (1-6). The present procedure depends on the insolubility of reduced hemoglobin S in a 2.24 mol/liter phosphate buffer. The commercially available “Sickledex” (Ortho Diagnostics, Raritan, N.J. 08869) is also thought to be based on this principle (6). Our method was compared with the standar...

Venous blood removed anaerobically from patients with sickle-cell anemia was transferred immediately into fixative, thus precluding significant loss or gain of oxygen by the cells. Electron microscopy demonstrated an intraerythrocytic fibrillar fine structure similar to that described in prior studies on erythrocytes sickled by deoxygenation in vitro. Observations reported here lead to these co...

Intrahepatic cholestasis of pregnancy is the most common pregnancy-related liver disease that occurs during pregnancy. It causes mortality and morbidity. In this review, intrahepatic (ICP) discussed with current literature.

Sickling of erythrocytes was rapidly and quantitatively inhibited at room temperature by 3.8 mM homoserine, asparagine, and glutamine but by no other amino acid.

A 36-year-old sickle cell anemia patient undergoing a pulmonary thromboendarterectomy required the use of cardiopulmonary bypass incorporating deep hypothermic circulatory arrest. Being aware of reported incidences of sickling crises, a team of the surgeon, anesthesiologist, hematologist, and perfusionist met to devise a plan of treatment. Treatment included preoperative and intraoperative exch...