نتایج جستجو برای: intranasal injection

تعداد نتایج: 164750  

Journal: :The Yale Journal of Biology and Medicine 1956
Robert R. Wagner

The respiratory epithelium is the only tissue of the adult mouse that is uniformly susceptible to influenza virus infection. The virus is most effective when administered intranasally"' although pulmonary lesions can be produced less regularly by direct intrathoracic inoculation.' Rickard and Francis'8 were the first to demonstrate virus multiplication and pulmonary consolidation after parenter...

2012
Marinus H. van IJzendoorn Ritu Bhandari Rixt van der Veen Karen M. Grewen Marian J. Bakermans-Kranenburg

We addressed the question how long salivary oxytocin levels remain elevated after intranasal administration, and whether it makes a difference when 16 or 24 IU of oxytocin administration is used. Oxytocin levels were measured in saliva samples collected from 46 female participants right before intranasal administration (at 9:30 a.m.) of 16 IU (n = 18) or 24 IU (n = 10) of oxytocin, or a placebo...

Journal: :The American journal of pathology 2001
E S Schelegle L J Gershwin L A Miller M V Fanucchi L S Van Winkle J P Gerriets W F Walby A M Omlor A R Buckpitt B K Tarkington V J Wong J P Joad K B Pinkerton R Wu M J Evans D M Hyde C G Plopper

To establish whether allergic asthma could be induced experimentally in a nonhuman primate using a common human allergen, three female rhesus monkeys (Macaca mulatta) were sensitized with house dust mite (Dermatophagoides farinae) allergen (HDMA) by subcutaneous injection, followed by four intranasal sensitizations, and exposure to allergen aerosol 3 hours per day, 3 days per week for up to 13 ...

Journal: :Journal of virology 2009
Koray Ozduman Guido Wollmann Sebastian A Ahmadi Anthony N van den Pol

Vesicular stomatitis virus (VSV) is the prototype virus for 75 or more negative-strand RNA viruses in the rhabdovirus family. Some of these viruses, including VSV, can cause neurological impairment or death upon brain infection. VSV has shown promise in the prevention and treatment of disease as a vaccine vector and an oncolytic virus, but infection of the brain remains a concern. Three VSV var...

Journal: :The Journal of Experimental Medicine 1938
E. R. Rickard Thomas Francis

Following the intraperitoneal inoculation of mice with large doses of epidemic influenza virus (50,000 to 1 million intranasal M.L.D.) it can be recovered from the lungs in high concentration, and pulmonary lesions of moderate extent may be observed. The virus reaches its highest titer in the lungs 48 to 72 hours after intraperitoneal injection and may persist for 10 days. Virus may be recovere...

Journal: :Drug research 2016
D Zetner L P H Andersen J Rosenberg

BACKGROUND Melatonin is traditionally administered orally but has a poor and variable bioavailability. This study aims to present an overview of studies investigating the pharmacokinetics of alternative administration routes of melatonin. METHODS A systematic literature search was performed and included experimental or clinical studies, investigating pharmacokinetics of alternative administra...

Journal: :Journal of clinical & cellular immunology 2013
Shuai Wu Ke Li Yaping Yan Bruno Gran Yan Han Fang Zhou Yang-Tai Guan Abdolmohamad Rostami Guang-Xian Zhang

The therapeutic potential of adult neural stem cells (aNSCs) has been shown in EAE, an animal model of MS, administered by either i.c.v. or i.v. injection. However, i.c.v. is an invasive approach, while the i.v. route of aNSCs is associated with a non-specific immune suppression in the periphery. Here we demonstrate that intranasal (i.n.) delivery of fluorescently labeled aNSCs resulted in thei...

2017
Yunxiao Kang Wensheng Yan Hui Fang Guoliang Zhang Yakun Du Lei Wang Huixian Cui Geming Shi

The current studies were aimed at evaluating the efficacy of intranasal pentoxifylline (Ptx) pretreatment in protecting mesodopaminergic system and hippocampus from oxidative damage of lithium-pilocarpine induced status epilepticus (SE) and the involvement of nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidant response elements pathway. Pentoxifylline was administered to rats intra...

Objective- This study aimed to compare sedation efficacy in intranasal administration of xylazine, diazepam and midazolam with or without ketamine in Chough. Design- To determine the sedation efficacy, an experimental in vivo study was employed. Animals- Seven healthy Choughs were examined in the current study. Procedu...

2017
Philippe Hermand Annick Vandercammen Emmanuel Mertens Emmanuel Di Paolo Vincent Verlant Philippe Denoël Fabrice Godfroid

The use of protein antigens able to protect against the majority of Streptococcus pneumoniae serotypes is envisaged as stand-alone and/or complement to the current capsular polysaccharide-based pneumococcal vaccines. Pneumolysin (Ply) is a key virulence factor that is highly conserved in amino acid sequence across pneumococcal serotypes, and therefore may be considered as a vaccine target. Howe...

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