T HE HUMAN body shows great economy in its handling of iron. Only small amounts of iron arefound in the excreta, and these amounts cannot be appreciably increased through loading body iron stores by oral ingestion,’ by parenteral iron administration2 or by multiple blood transfusions.3 These observations imply that iron is rigidly conserved by the body and that no attention need be directed tow...

Recombinant epoetin therapy and correction of the chronic anemia of renal failure have greatly reduced the number of red cell transfusions and hence the propensity to iron overload. The majority of HD patients require intravenous iron therapy to achieve the hematocrit levels that correspond to improved outcome measures. Although the short-term benefits of intravenous iron have been clearly defi...

T HE HUMAN body shows great economy in its handling of iron. Only small amounts of iron arefound in the excreta, and these amounts cannot be appreciably increased through loading body iron stores by oral ingestion,’ by parenteral iron administration2 or by multiple blood transfusions.3 These observations imply that iron is rigidly conserved by the body and that no attention need be directed tow...

Iron deficiency is a leading cause of anaemia in pregnancy. The present study aimed to compare the efficacy of intramuscular and intravenous iron therapy in improving iron deficiency anaemia in pregnancy and restoring iron stores, compare the obstetric outcome in the two groups and evaluate the safety of intravenous iron sucrose. This was a prospective study, where 200 anemic antenatal women wi...

Iron deficiency is an important cause of anemia in patients with chronic kidney disease (CKD), but intravenous iron is infrequently used among patients who are not on dialysis. Ferumoxytol is a novel intravenous iron product that can be administered as a rapid injection. This Phase III trial randomly assigned 304 patients with CKD in a 3:1 ratio to two 510-mg doses of intravenous ferumoxytol wi...

Anaemia is the most frequent, though often neglected, comorbidity of inflammatory bowel disease (IBD). Here we want to briefly present (1) the burden of anaemia in IBD, (2) its pathophysiology, which mostly arises from bleeding-associated iron deficiency, followed by (3) diagnostic evaluation of anaemia, (4) a balanced overview of the different modes of iron replacement therapy, (5) evidence fo...

In hereditary hemorrhagic telangiectasia (HHT), frequent episodes of nasal and gastrointestinal bleeding commonly lead to iron-deficiency with or without anemia. In the retrospective study presented here we assessed the iron stores, as determined by analysis of plasma ferritin, during oral and intravenous iron supplementation, respectively, in a population of iron-deficient non-anemic HHT patie...

Moebus et al. (1) reported that erythropoiesis stimulating agents (ESAs) can treat chemotherapy-induced anemia (CIA) in breast cancer patients receiving adjuvant chemotherapy with no effect on overall survival, relapse-free survival, or intramammary relapse. They also conclude that epoetin increased thrombosis. Their treatment protocol did not include adequate iron replacement. Although iron st...

BACKGROUND AND OBJECTIVES Intravenous iron is a key component of anemia management for chronic kidney disease (CKD). Ferumoxytol is a unique intravenous iron product that can be administered as a rapid injection in doses up to 510 mg. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This was a randomized, open-label, controlled, multicenter Phase 3 trial to evaluate the safety and efficacy of in...