Purpose: Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due to the absence of truly restricted antigen expression and potential safety concerns with "on-target off-tumor" activity. Here, we have optimized HER2-CAR T cells for the treatment of breast to brai...

Papillary glioneuronal tumor (PGNT) is a rare brain tumor (World Health Organization grade I) with a glioneuronal dual nature. It has a characteristic morphological pattern composed of astroglial pseudopapillary structures and interpapillary neurocytic elements. The tumor usually occurs in the supratentorial region in children and young adults, with a predilection for the temporal lobe. It is t...

A 70-year-old woman presented with a 2-year history of progressive difficulty in walking with frequent falls. Neurologic examination showed postural instability with backward falls, vertical supranuclear gaze palsy with normal vestibular-ocular reflex, rigidity, and pyramidal signs in the right limbs. There was no clinical response to levodopa. Laboratory serologic tests had normal results. MRI...

Intraventricular meningiomas account for 9.8-14% of all intraventricular tumors and for 20% of lateral ventricle tumors [1,2]. Meningiomas of the lateral ventricle constitute 0.5-4.5% of all intracranial meningiomas [3,4]. Between 60% and 94% of them arise from the choroid plexus at the trigone. The predilection for the trigone may be attributed to the abundance of choroid plexus arachnoidea. T...

This case series describes the surgical removal of lateral ventricular tumors using a transcallosal approach, long-term follow-up, and magnetic resonance imaging (MRI) results 3 dogs. Two were benign choroid plexus (CPT). One was grade 2 astrocytoma. Complete tumor achieved approach. All dogs had ventriculomegaly which remained static or progressed during follow-up period. epileptic seizures be...

Central neurocytoma (CN) is a rare and elusive tumor. The relationship between clinical outcome, tumor nature, treatment of CN remains controversial. There were eight patients in our hospital from 2014 to 2021, the prevalence accounted for 0.36% brain tumors. All them underwent surgical removal, two combined with adjuvant radiotherapy (RT). We found that four without complications had small tum...

BACKGROUND Intraventricular oligodendroglioma remains a rare diagnosis, with high-grade/anaplastic IVO being an even rarer subtype. These lesions vary in regard to tumor grading and clinical presentation, as compared with their intraparenchymal counterparts. A case report and review of the previous literature regarding IVO and tumor grading were conducted. CASE DESCRIPTION A case report of a ...

BACKGROUND: Central neurocytoma (CN) is an infrequent and non-malignant neuro-epithelial tumor. CN mostly found in lateral ventricle may generate obstructive hydrocephalus. Surgical-radiation can increase patient survival prognosis. This case report presented a rare about 30-year-old female with CN. CASE PRESENTATION: came to the hospital severe headache vomiting. Brain MRI showed heterogeneous...

BACKGROUND Spindle cell oncocytoma (SCO) is a rare nonfunctioning neoplasm of the adenohypophysis, and was first described in 2002. SCO has been categorized as a separate entity by the 2007 World Health Organization (WHO) and is classified as a Grade 1 tumor of the central nervous system (CNS). Review of the literature has shown that 33 cases of SCO have been reported to date, and most of them ...

INTRODUCTION Intraventricular endoscopic operations are usually undertaken in patients with an enlarged ventricular system that provides good access to the ventricles, proper anatomic orientation and safety of maneuvers within the ventricles. AIM The preliminary assessment of the feasibility of endoscopic procedures in cases occurring without hydrocephalus. MATERIAL AND METHODS Eleven patie...