ObjectivesThis cost-effectiveness analysis (CEA) of 4CMenB infant vaccination in England comprehensively considers the broad burden serogroup B invasive meningococcal disease (MenB IMD), which has not been considered, or was only partially considered previous CEAs.MethodsA review MenB CEAs conducted to identify aspects evaluation costs and health outcomes IMD. To inform model structure comprehe...

Introduction: While there is a significant amount of information about invasive meningococcal disease (IMD), carriage, and vaccines in children adolescents, data older adults are limited. Studies carriage transmission modeling can be utilized to predict the spread IMD guide prevention treatment strategies. Our study’s main objective was assess prevalece Neisseria meningitidis (Nm) serogroup dis...

BACKGROUND Public health programs to prevent invasive meningococcal disease (IMD) with monovalent serogroup C meningococcal conjugate vaccine (MCV-C) and quadrivalent meningococcal conjugate vaccines (MCV-4) in infancy and adolescence vary across Canadian provinces. This study evaluated the cost-effectiveness of various vaccination strategies against IMD using current and anticipated future pri...

BACKGROUND Neisseria meningitidis can cause severe infection in humans. Polymorphism of Complement Factor H (CFH) is associated with altered risk of invasive meningococcal disease (IMD). We aimed to find whether polymorphism of other complement genes altered risk and whether variation of N. meningitidis factor H binding protein (fHBP) affected the risk association. METHODS We undertook a case...

Invasive meningococcal disease (IMD) completeness of reporting has never been assessed in New York City (NYC). We conducted a capture-recapture study to assess completeness of reporting, comparing IMD reports made to the NYC Department of Health and Mental Hygiene (DOHMH) and records identified in the New York State hospital discharge database [Statewide Planning and Research Cooperative System...

Abstract Expansion of quinolone-resistant Neisseria meningitidis clone ChinaCC4821-R1-C/B from sequence type (ST) 4821 clonal complex (CC4821) caused a serogroup shift A to C invasive meningococcal disease (IMD) in China. To determine the relationship among globally distributed CC4821 meningococci, we analyzed whole-genome data 173 meningococci isolated 4 continents during 1972–2019. These clus...

Since August 2010, 22 cases of invasive meningococcal disease (IMD) among men who have sex with men (MSM) have been reported to the New York City Department of Health and Mental Hygiene (NYC DOHMH) (1). Seven of these men died. The mean age was 34 years, 50% were African American, and 55% were infected with HIV. Among the 12 patients with HIV infection, the median CD4 count was 525 10 cells/L, ...

A number of countries now include meningococcal vaccines in their routine immunization programs. This review focuses on different approaches to including meningococcal vaccines in country programs across the world and their effect on the burden of invasive meningococcal disease (IMD) as reflected by pre and post-vaccine incidence rates in the last 20 years. Mass campaigns using conjugated menin...

The incidence of invasive meningococcal disease (IMD) in Germany in 2003 was estimated by the two-source capture-recapture method. As a unique personal identifier was unavailable, cases with IMD tested at the National Reference Centre for Meningococci (NRZM) were matched with cases reported to the Robert Koch Institute (RKI) through the statutory surveillance system by using demographic and dis...