BACKGROUND Although nail psoriasis affects a marked proportion of patients with psoriasis and causes significant psychological stress, only few epidemiological data characterizing patients with nail involvement are available. OBJECTIVES To gain robust data on the epidemiology and disease burden of nail psoriasis in Germany. METHODS Two nationwide, noninterventional, cross-sectional studies ...

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and se...

Several meta-analyses have investigated the association between physical activity and affective states and have found evidence suggesting that exercise exerts a positive effect on affective state. However, in this field of research, most studies have conducted between-subject analyses. Nonetheless, there is more and more interest in the within-subject associations between physical activity and ...

Joint involvement is a common manifestation in systemic lupus erythematosus (SLE). According to the SLE disease activity index 2000 (SLEDAI-2K), joint involvement is present in case of ≥2 joints with pain and signs of inflammation. However this definition could fail to catch all the various features of joint involvement. Alternatively the Swollen to Tender joint Ratio (STR) could be used. This ...

Background and Objective: The primary goal of this study is to develop a rigorous understanding ofthe correlation between COX-2 expression and malignant melanoma prognostic factors. Material and Methods: In this cross-sectional study, we analyzed 60 cases of cutaneous malignant melanoma. The related stained slides were reviewed by two pathologists. The re...

In a recent meta-analysis, only 53% of disorganized infants were predicted by parental Unresolved states of mind on the Adult Attachment Interview (AAI). The goal of this study was to identify additional predictors of infant disorganization on the AAI by developing and validating an interview-wide coding system for Hostile/Helpless (H/H) parental states of mind with respect to attachment. Mater...

background and aims: ankylosing spondylitis (as) is an idiopathic chronic inflammatory disease mainly involves sacroiliac and axial joints; but it may also have extra-articular involvement. accordingly, this study was designed to determine the frequency of cardiac involvement among patients with ankylosing spondylitis. methods: this study was performed as a descriptive-analytical cross-section...

behçet’s disease (bd) is a multisystem disorder with potential ability to influence the pregnancy outcome and pregnancy is associated with several physiologic alterations which can lead to potential changes in the course of the disease. we studied 77 pregnancies in 69 women with bd. the disease activity was calculated by two methods for three periods of before, during and after pregnancy to eva...

OBJECTIVES To describe a modification of the index of clinical consequences of untreated dental caries [pulpal involvement, ulceration, fistula and abscess (PUFA/pufa) index] to pulpal involvement-roots-sepsis (PRS/prs) and to compare the two indices using the example of caries in primary molar teeth in children aged 6-8 years. SUBJECTS AND METHODS The study sample included 542 children aged ...