Radioactive iodine (1311) has a part to play in the therapy of two thyroid disorders, carcinoma and thyrotoxicosis, by virtue of the selective concentration of it which occurs in functioning thyroid cells. The latter represent the only significant site of concentration of the iodide ion in the body, this occurring because of the necessity to incorporate iodine into the molecule of the thyroid h...

Correct staging of prostate cancer is an unmet clinical need. Radionuclide targeting of prostate-specific membrane antigen (PSMA) with 111In-labeled capromab pendetide (ProstaScint) is a clinical option for prostate cancer staging. We propose the use of 124I-labeled capromab to decrease the retention of radioactivity in healthy organs (due to the non-residualizing properties of the radiolabel)....

BACKGROUND Measurement of radioactive iodine uptake (RAIU) is an important aspect of the assessment and treatment of patients with hyperthyroidism. Its uncertainty affects how much of a true change in RAIU can be detected as well as appropriateness of the therapy dosage upon which it is based. In this study, a method of estimating the reproducibility and least significant change (LSC) values fo...

Materials with apatite crystal structure have a great potential for incorporating the long-lived radioactive iodine isotope (129I) in the form of iodide (I) from nuclear waste streams. Because of its durability and potentially high iodine content, the apatite waste form can reduce iodine release rate and minimize the waste volume. Crystal structure and composition of apatite (A5(XO4)3Z) was inv...

background: the aim of the study was to evaluate the third trimester urinary iodine excretion and to assess its relation with newborns thyroid function. materials and methods: a total  of  208 healthy third trimester pregnant women without previous history of thyroid disease were included in the study. urinary iodine levels of mothers were measured and neonatal tsh levels were screened on the 3...

background: goiter is thyroid enlargement, which is the most common visible symptom of iodine deficiency. some studies have shown iodine deficiency in water, soil, and food in many places worldwide. we aimed to determine the prevalence of goiter and the association between urine iodine levels in children with severity and prevalence of goiter in mountainous villages of kashan city (center of ir...

Immunoglobulin G (IgG) antibodies to carcinoembryonic antigen (CEA) were labelled with radioactive indium (111In) or iodine (131I) and a comparison made of their value in locating CEA producing tumours. Eleven patients given 111In-anti-CEA had 31 tumours as judged by a combination of all techniques. Of these, 28 were detected by 111In-anti-CEA and 26 by conventional clinical techniques. Five of...

The kinetics of iodination at the 3-position of 1.3-dirnethyland [3-2HI]-1 ,3-dimethyl-indolin-2-one are reported for buffered mildly alkaline 50% (w /w) aqueous methanol solutions at 25". Unlike the iodination of many ketones these reactions (even in the presence of excess of substrate and with large amounts of added iodide ion) do not follow a zero-order rate expression, but show behaviour in...

The treatment of hyperthyroidism is targeted at reducing the production of thyroid hormones by inhibiting their synthesis or suppressing their release, as well as by controlling their influence on peripheral tissue (conservative therapy, medical treatment). Radical treatment includes surgical intervention to reduce the volume of thyroid tissue or damage of the mechanisms of thyroid hormone synt...