OBJECTIVE There is a high incidence of hypophosphataemia in the critically ill. It is known that even moderate hypophosphataemia can produce a variety of adverse consequences. Many phosphate replacement regimens have been suggested, most are conservative and few validated in the critical care environment. We designed a study to determine the apparent volume of distribution of phosphate and quan...

Osteoporosis is the index disease for calcium deficiency, just as rickets/osteomalacia is the index disease for vitamin D deficiency, but there is considerable overlap between them. The common explanation for this overlap is that hypovitaminosis D causes malabsorption of calcium which then causes secondary hyperparathyroidism and is effectively the same thing as calcium deficiency. This paradig...

The effects of hyperventilation on the pattern-reversal visual evoked potential (VEP) were studied in seven normal subjects and 13 multiple sclerosis patients with visual pathway involvement. Significantly greater reductions in P100 latency occurred in the multiple sclerosis patients than in controls and normalisation of the half-field response topography occurred in one patient after hypervent...

We use the full broad-band XMM-Newton EPIC data to examine the X-ray spectrum of the nearby Seyfert 2 galaxy NGC 1068, previously shown to be complex with the X-ray continuum being a sum of components reflected/scattered from cold (neutral) and warm (ionised) matter, together with associated emission line spectra. We quantify the neutral and ionised reflectors in terms of the luminosity of the ...