Polymorphisms in the TNIP1 gene encoding A20-binding inhibitor of NF-κB1 (ABIN1) predispose to lupus and other autoimmune diseases in at least eight human populations. We found previously that knock-in mice expressing a ubiquitin-binding-defective mutant of ABIN1 (ABIN1[D485N]) develop autoimmunity as they age and succumb to a disease resembling lupus nephritis in humans. In this article, we re...

Kymera has developed selective IRAK4 degraders for the treatment of autoimmune and inflammatory diseases where IL-1R/TLR activation plays a central role in driving response. In skin, like hidradenitis suppurativa, keratinocytes are active mediators that triggered by IL1R signaling. signals through myddosome which is dependent on kinase scaffold functions Interleukin-1 receptor associated 4 (IRA...

In recent years innate immunity has moved into focus of therapeutically approaches due to its ability drive downstream adaptive responses. Modulators immune responses are expected have high therapeutic potential across immune-mediated inflammatory diseases (IMIDs). The kinase IRAK4 integrates signaling receptors acting at the interface between and (e.g. TLRs, IL-1R, IL-18R). Here, we profiled a...