BACKGROUND Omeprazole is metabolized predominantly by CYP2C19, a polymorphically expressed enzymes that show marked interindividual and interethnic variation. These variations cause a substantial differences that have been reported in the pharmacokinetics of omeprazole. The aim of the present study was to evaluate the pharmacokinetic parameters of omeprazole in a random Iranian population. ME...

Single-Nucleotide Polymorphism of rs11061971 (+219 A>T) in Adiponectin Receptor 2 (AdipoR2) Gene and its Association with Risk Type Diabetes among Iranian Population

introduction : pemphigus vulgaris (pv) is a relatively rare autoimmune disease characterized by blistering of the skin and mucosa. the main objective of this study was to investigate the possible association between the 5-httlpr polymorphism and pv in iranian patients. for this, 112 pv and 100 controls were enrolled in this study. materials and methods : in this case-control study, genomic dna ...

the environmental procarcinogen which are responcible for carcinogenesis, to form the proximate carcinogen, they require metabolic activation by drug metabolizing enzymes. the cyp3a subfamily enzymes play an important role in elimination of drugs. the substrates for cyp3a4 enzyme include drugs, and endogenous substances. therefore, allelic changes in the coding regions of cyp3a4, increases the ...

aim: the objective of this study was to evaluate the time trend of helicobacter pylori ( h. pylori ) prevalence and presence of intestinal metaplasia over the period of 7 years in gastritis iranian patients. background: h. pylori are the major causal factor in chronic gastritis. its acquisition leads to a chronic, usually lifelong, inflammation of the gastric mucosa, which may gradually progres...

AIMS The KCNJ11 gene has a strong effect on glucose-stimulated insulin secretion. Common polymorphism KCNJ11 E23K has been reported to be associated with type 2 diabetes in various European-descent populations. However, there were inconsistent results in previous studies in Asian populations, and no study has been carried out in the Iranian population. We examined the contribution of KCNJ11 E23...