FLICE-inhibitory protein (FLIP) is an endogenous inhibitor of the signaling pathway triggered by the activation of death receptors. Here, we reveal a novel biological function for the long form of FLIP (FLIP-L) in neuronal differentiation, which can be dissociated from its antiapoptotic role. We show that FLIP-L is expressed in different regions of the mouse embryonic nervous system. Immunohist...

c-FLIPs (c-FLICE inhibitory proteins) play an essential role in regulation of death receptor-induced apoptosis. Multiple splice variants of c-FLIP have been described on the mRNA level; so far only two of them, c-FLIP(L) and c-FLIP(S,) had been found to be expressed at the protein level. In this report, we reveal the endogenous expression of a third isoform of c-FLIP. We demonstrate its presenc...

TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective cytokine with potential anticancer activity and is currently under clinical testing. Head and neck squamous cell carcinoma (HNSCC), like other cancer types, exhibits varied sensitivity to TRAIL. MLN4924 is a newly developed investigational small molecule inhibitor of NEDD8-activating enzyme with potent anticancer activity. This ...

OBJECTIVE c-FLIP is a natural homologue of caspase 8, and may antagonize activation of death pathways mediated by FADD. c-FLIP is highly expressed in the heart, and a recent report suggests that c-FLIP may protect against certain types of myocyte death. The present study was designed to define the expression patterns of c-FLIP in the heart. METHODS The expression pattern of c-FLIP in end-stag...

Glutamatergic transmission converging on calcium signaling plays a key role in dendritic differentiation. In early development, AMPA receptor (AMPAR) transcripts are extensively spliced and edited to generate subunits that differ in their biophysical properties. Whether these subunits have specific roles in the context of structural differentiation is unclear. We have investigated the role of n...

In this paper, we consider a general time-space discrete host-parasitoid model with the periodic boundary conditions. We analyzed and obtained some usual conditions, such as Turing instability occurrence, Flip bifurcation Neimark-Sacker occurrence. also find several multiple phenomena, 1 : 2 Resonance, Neimark-Sacker-Flip bifurcation, Neimark-Sacker-Neimark-Sacker Neimark-Sacker-Flip-Flip induc...

The logic construction of a double-edge-triggered (DET) flip-flop, which can receive input signal at two levels of the clock, is analyzed and a new circuit design of CMOS DET flip-flop is proposed. Simulation using SPICE and a 1 micron technology shows that this DET flip-flop has ideal logic functionality, a simpler structure, lower delay time and higher maximum data rate compared to other exis...

FLICE-inhibitory protein, FLIP (Casper/I-FLICE/FLAME-1/CASH/CLARP/MRIT), which contains two death effector domains and an inactive caspase domain, binds to FADD and caspase-8, and thereby inhibits death receptor-mediated apoptosis. Here, we characterize the inhibitory effect of FLIP on a variety of apoptotic pathways. Human Jurkat T cells undergoing Fas ligand-mediated apoptosis in response to ...

Power reduction has become a vital design goal for sophisticated design applications, whether mobile or not. dropping power consumption in design enables better, cheaper products to be designed and power-related chip failures to be minimized. Researchers have shown that multi-bit flip-flop is an effective method for clock power consumption reduction. The underlying idea behind multi-bit flip-fl...