background: during the detorsion of a torsioned ovary, oxidant agents are released and melatonin as an antioxidant can reduce ischemia. we studied the histopathological changes after using melatonin on experimental torsioned ovary in cat. objective: the aim of this experimental study was to investigate the effects of melatonin on histopathological changes in torsion – detorsion injury in cat ov...

postconditioning is a simple and safe strategy for cardioprotection and infarct size limitation. our previous study showed that oxytocin (ot) exerts postconditioning effect on ischemic/reperfused isolated rat heart. the aim of this study was to investigate the involvement of ot receptor, mitochondrial atp-sensitive potassium channel (mkatp), nitric oxide (no) and cyclooxygenase (cox) pathways i...

Ovarian torsion is one of the gynecological emergencies that affect ovarian tissue integrity and fertility. In this study, we aim to investigate effects Momordica charantia (MC) on injury induced by ischemia-reperfusion. Twenty-four rats were assigned three groups: control group, ischemia-reperfusion (I/R) group IR + MC group. 600 mg/kg extract given via orogastric route. 3-hour ischemia reperf...

objective(s): to evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (ir) injury. materials and methods: eighteen female wistar albino rats were used in control, ir, and ir+edosteine (ir-e) groups, (n=6 in each). the ir-e group received the erdosteine for seven da...

background renal ischemia reperfusion (ir) contributes to the development of acute renal failure (arf). oxygen free radicals are considered principal components involved in the pathophysiological tissue alterations observed during renal ir. objective in this study, we compared the effects of melatonin (mel) and erythropoietin (epo), which are known antioxidant and anti-inflammatory agents, in i...

anandamide is an endogenous ligand for cannabinoid receptors and has endothelial protective effect against ischemic preconditioning. the purpose of this study was to investigate the effects of cannabinoids on reperfusion injury due to testicular torsion-detorsion (t/d). a total of 36 adult male sprague-dawley rats were divided into 6 groups. testicular ischemia was achieved by twisting the righ...

objective(s): some histopathological alterations take place in the ischemic regions following brain ischemia. recent studies have demonstrated some neuroprotective roles of crocin in different models of experimental cerebral ischemia. here, we investigated the probable neuroprotective effects of crocin on the brain infarction and histopathological changes after transient model of focal cerebral...

Background: Renal ischemia reperfusion injury may occur in a variety of clinical situations, following a transient drop in total or regional blood flow to the kidney. This study was performed to investigate the protective effects of different antioxidants such as vitamin C, vitamin E, hydrocortisone and combination of these agents against experimental renal ischemia-reperfusion injury....

Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectom...

background: stroke is the third leading cause of invalidism and death in industrialized countries. there are conflicting reports about the effects of angiotensin ii on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. in this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin ii at1 receptor b...