The new inotropic agent pren lte 01 was admini te in a canine model of acute ischemic heart failure d int and in venously patients witn severe chronic heart failure. Experimental heart failure in anesthetized dogs was induced by two vessel coronary artery constriction and intravenous prenalterol (0.005-15 ug/kg/min) was compared to dobutamine (0.001-30 ug/kg/min) and saline. Significant dose-de...

INTRODUCTION AND OBJECTIVES Coronary flow reserve (CFR) is impaired not only in ischemic heart disease, but also in cardiac diseases that may or may not course with heart failure. The aim of the present study was to determine if the severity of heart failure can influence CFR impairment. METHODS Forty patients with non-ischemic heart disease and heart failure were studied 41 times. Four group...

Surgical interventions for ischemic or non-ischemic heart failure refractory to medical treatment include the implantation of an artificial heart, tissue engineering medicine, and myocardial substitute, in addition to conventional coronary revascularization for ischemic heart disease (IHD) and undersized mitral annuloplasty (UMAP) for functional mitral regurgitation (FMR) causing myocardial dam...

Heart failure is a clinical syndrome of ischemic and non ischemic etiology. Imaging plays a major part in diagnosing its cause, course, and prognosis. In the ischemic heart, positron emission tomography (PET), by, for example, assessing myocardial perfusion and glucose metabolism, and magnetic resonance imaging (MRI), by evaluating myocardial function, myocardial necrosis, and/or inotropic cont...

Heart failure is supposed to be one of the most important causes of morbidity and mortality in the developed countries (McMurray JJ, 2000) (Cowie MR, 2000). It is not a disease by itself but it is a consequent condition of a number of co-existing factors including arterial hypertension, coronary artery heart disease and myocardiopathies. The quality of life of the patient is affected in heart f...

long-term mechanical circulatory support is a life-saving technology while briding to heart transplantation. it increases the quality of life and preserves end-organ function for patients with  advanced heart failure. the number of patients with advanced heart failure scheduled for heart transplantation before comorbidities escalate is on the rise. however, the device function is complicated by...

CONTEXT AND OBJECTIVES The obesity paradox has already been established in relation to heart failure, but it is not known which obesity indicator best reflects this phenomenon. The aim of this study was to evaluate the association between obesity indexes and mortality among patients with heart failure. DESIGN AND SETTING Cohort study conducted in the Department of Cardiology of Hospital Nossa...