background: peroxisome proliferator activated receptor gamma (pparγ), a member of nuclear receptor superfamily, comprises two isoforms in mouse. these two isoforms are encoded by different mrnas, which are arisen by alternative promoter usage. there are two promoter regions upstream of pparγ gene. a 3 kb fragment, containing several transcription factor binding sites, acts as pparγ1 promoter re...

objective(s):previous studies demonstrate that changes in pre-mrna splicing play a significant role in human disease development. furthermore, many cancer-associated genes are regulated by alternative splicing. there are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. located on the x chromosome, ...

Due to alternative splicing events in eukaryotic species, the identification of mRNA isoforms (or splicing variants) is a difficult problem. Traditional experimental methods for this purpose are time consuming and cost ineffective. The emerging RNA-Seq technology provides a possible effective method to address this problem. Although the advantages of RNA-Seq over traditional methods in transcri...

Abstract Recent findings implicate the complement C4 gene in gray matter loss schizophrenia. In a large cohort of patients with first-episode psychosis (FEP), we aimed to (1) characterize frequency copy number variations (CNVs) and HERV-K Ins/Del events as compared that healthy controls (HCs) (2) evaluate whether structural variants influence baseline clinical symptoms treatment response amisul...

Collybistin (CB) is a guanine nucleotide exchange factor (GEF) selectively localized at GABAergic and glycinergic postsynapses. Analysis of mRNA shows that several isoforms collybistin are expressed in the brain. Some have SH3 domain (CBSH3+) some no (CBSH3?). The CBSH3+ mRNAs predominantly over CBSH3?. However, an immunoblot study mouse brain homogenates, only protein were detected, proposing ...

The glial fibrillary acidic protein (GFAP) is a type III intermediate filament (IF) that highly expressed in astrocytes, neural stem cells, and gliomas. Gliomas are heterogeneous group of primary brain tumors arise from glia cells or rely on accurate diagnosis for prognosis treatment strategies. GFAP differentially between glioma subtypes and, therefore, often used as diagnostic marker. However...

OPA1 is a dynamin-family GTPase that the central mediator of mitochondrial inner membrane fusion. The Opa1 gene generates both long and short isoforms (l-OPA1 s-OPA1) through proteolytic processing. We identify new s-OPA1 show it functions with l-OPA1 to tune level