The incidence of pancreatic injury following blunt abdominal trauma is rare. A timely accurate diagnosis of such injury is difficult and also the management remains controversial. Here, we reported the successful use of laparoscopy to diagnose, characterize and treat blunt pancreatic trauma in a 28-year-old male patient involved in a motor vehicle crash. An abdominal computed tomography scan sh...

intraductal papillary mucinous neoplasms (ipmns) are rare pancreatic tumours, accounting for less of 1-2% of all neoplasms of the gland. main characteristics of ipmns are their favourable prognosis as these pre-malignant or frankly malignant lesions are usually slow-growing tumours and radical surgery is frequently possible. according with the localization of the lesions, three different entiti...

Hydatidosis is an endemicdisease in Morocco. Localization the pancreas very rare especially when isolated. We report case of a patient admitted emergency room for suppurated pancreatic collection, about 15 cm diameter, resembling fistulized Pseudo-pancreatic cyst, or cystic tumoror hydatid cyst. In spite initial empirical antibiotic therapy, unfavorable evolution led us to perform exploratory l...

The renin-angiotensin system contributes to pathological processes in a variety of organs. In the pancreas, blocking the angiotensin II (AII) type 1 receptor (AT1) attenuates pancreatic fibrogenesis in animal models of pancreatitis. Because the role of the AII type 2 receptor (AT2) in modulating pancreatic injury is unknown we investigated the role of AT2 in pancreatic injury and fibrosis. Panc...

Obestatin, a newly discovered peptide encoded by the ghrelin gene, induces the expression of genes regulating pancreatic beta-cell differentiation, insulin biosynthesis, and glucose metabolism. It also activates antiapoptotic signaling pathways such as phosphoinositide 3-kinase (PI3K) and ERK1/2 in pancreatic beta-cells and human islets. Since these kinases have been shown to protect against my...

abstract reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. it has been shown that progesterone and cilostazol possess antioxidant properties. the present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

Mechanisms leading to acute pancreatitis after a fat-enriched meal combined with excess alcohol are incompletely understood. We have studied the effects of alcohol and fat (VLDL) on pancreatic acinar cell (PAC) function, oxidative stress, and repair mechanisms by pancreatic stellate cells (PSC) leading to fibrogenesis. To do so, PAC (rat) were isolated and cultured up to 24 h. Ethanol and/or VL...