isolated perfused rat liver

m karami from the department of toxicology, school of pharmacy, tehran university of medical sciences m ghazi-khansari the departments of pharmacology school of medicine, tehran university of medical sciences, tehran, i.r. iran m rezayat the departments of pharmacology school of medicine, tehran university of medical sciences, tehran, i.r. iran b minaei the departments of histology, school of medicine, tehran university of medical sciences, tehran, i.r. iran m abdollahi from the department of toxicology, school of pharmacy, tehran university of medical sciences o sabzevari from the department of toxicology, school of pharmacy, tehran university of medical sciences

2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. it appears that tcdd is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. the prominent hepatotoxic effect of tcdd is progressive centrilobular necrosis. the is...

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THE ISOLATED PERFUSED BOVINE LIVER

Journal: :Journal of Experimental Medicine 1961

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Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver

2016

Reza Heidari Neda Esmailie Negar Azarpira Asma Najibi Hossein Niknahad

Sulfasalzine is a widely administered drug against inflammatory-based disorders in human. However several cases of liver injury are associated with its administration. There is no stabilized safe protective agent against sulfasalazine-induced liver injury. Current investigation was designed to evaluate if N-acetylcysteine (NAC) and dithioteritol (DTT) as thiol reducing agents and/or vitamins C ...

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