objective(s) the aim of this study was to investigate the overall effect of cardiac vasoactive factors during coronary occlusion and reperfusion on peripheral vascular tone, using a sequential isolated rabbit heart-ear perfusion model. materials and methods isolated ears were perfused with the effluent of isolated hearts subjected to ischemia (30 min) and reperfusion (180 min, n=6). the compara...

introduction: ouabaine is a well-known atrioventricular (av) node depressant agent, but its effects on functional properties of the av node have not been cleared. the aim of the present study was to determine how ouabaine administration modifies the rate-dependent properties of the av node. methods: selective stimulation protocols were used to quantify independently electrophysiological propert...

Background: Calcium overload and free radical mediated damage in the mitochondria is the most important pathological changes associated with myocardial ischemic-reperfusion injury. The verapamil post-treatment has been previously reported to prevent reperfusion-induced myocardial injury but functional recovery may be delayed due to the drug's inherent direct myocardial depression effect. In the...