A patient with acute dementia underwent imaging of the brain with technetium-99m hexamethylpropyleneamine oxime single-photon emission computed tomography. Regional perfusion abnormalities were identified in multiple locations, particularly in the left frontal lobe. This information was used to direct an open brain biopsy, which led to a diagnosis of Creutzfeldt-Jacob disease.

THE MOUSE CELL SURFACE PROTEIN TOSO REGULATES FAS/FASLIGAND INDUCED APOPTOSIS THROUGH ITS BINDING TO FADD * Yahui Song and Chaim O. Jacob From the Department of Medicine and Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles, CA 90089 Running title: Role of TOSO in apoptosis Address correspondence to: Chaim O. Jacob, Department of Medicine, ...

A patient presenting with the characteristic clinical features of Steele-Richardson-Olszewski syndrome is described, in whom neuropathological examination revealed atypical features, including extensive cortical and subcortical gliosis. The clinical and pathological features are discussed with particular reference to Creutzfeldt-Jacob disease and it is proposed that the case should be classifie...