Viral antigens in permissive cells infected with JC virus, K virus, and SA12 virus were reactive in immunofluorescence tests to antisera against sodium dodecyl sulfate-disrupted simian virus 40 capsids and polyoma VP1. The major capsid polypeptides of all papovaviruses of the simian virus 40-polyoma subgroup are immunologically related.

Isolation of a strain of polyomavirus, designated COL, from the brain of a patient with progressive multifocal leucoencephalopathy is described. The COL strain is antigenically similar to JC polyomavirus, previously isolated from a brain affected by progressive multifocal leucoencephalopathy and is unrelated to BK, another human polyomavirus isolated from urine. Immunological cross testing of v...

Dear Editor, Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus (JCV). PML is caused by lytic infection of glial cells in severely immunosuppressed patients and is often fatal. JCV infects most people in childhood and is usually asymptomatic. Afterwards, the virus persists in the body in a latent state, where viral protein expression ...