نتایج جستجو برای: kal1 gene

تعداد نتایج: 1141383  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز - دانشکده کشاورزی 1390

تنش دمای پایین یکی از مهم ترین عوامل محیطی است که عملکرد گیاهان را محدود می نماید. شبکه وسیعی از ژن های مختلف در تنظیم تحمل گیاه به این تنش نقش ایفا می نمایند. در این تحقیق، نخست 921 عدد از ژن های مذکور از تحقیقات و مقالات معتبر علمی استخراج گردید و سپس به منظور شناسایی ژن های مشابه با آنها در ژنوم کامل دو گیاه سیب (malus domestica)و انگور (vitis vinifera)، توالی آمینو اسیدی این ژن ها در گیاه م...

Journal: :Journal of medical genetics 2005
H G Kim S R Herrick E Lemyre S Kishikawa J A Salisz S Seminara M E MacDonald G A P Bruns C C Morton B J Quade J F Gusella

W e have established the Developmental Genome Anatomy Project (DGAP; //dgap.harvard.edu) to take advantage of the unique opportunity to locate genes of developmental importance provided by apparently balanced chromosomal rearrangements associated with phenotypic abnormalities. By positional cloning at or near the breakpoints, we aim to identify the crucial disease genes whose functions have bee...

2015
Rosalie Ridzewski Diana Rettberg Kai Dittmann Nicole Cuvelier Simone Fulda Heidi Hahn

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is divided into two major histological subgroups, i.e., embryonal (ERMS) and alveolar RMS (ARMS). RMS can show HEDGEHOG/SMOOTHENED (HH/SMO) signaling activity and several clinical trials using HH inhibitors for therapy of RMS have been launched. We here compared the antitumoral effects of the SMO inhibitors GDC-0449, ...

Journal: :The Journal of clinical endocrinology and metabolism 2012
Taneli Raivio Magdalena Avbelj Mark J McCabe Christopher J Romero Andrew A Dwyer Johanna Tommiska Gerasimos P Sykiotis Louise C Gregory Daniel Diaczok Vaitsa Tziaferi Mariet W Elting Raja Padidela Lacey Plummer Cecilia Martin Bihua Feng Chengkang Zhang Qun-Yong Zhou Huaibin Chen Moosa Mohammadi Richard Quinton Yisrael Sidis Sally Radovick Mehul T Dattani Nelly Pitteloud

CONTEXT Kallmann syndrome (KS), combined pituitary hormone deficiency (CPHD), and septo-optic dysplasia (SOD) all result from development defects of the anterior midline in the human forebrain. OBJECTIVE The objective of the study was to investigate whether KS, CPHD, and SOD have shared genetic origins. DESIGN AND PARTICIPANTS A total of 103 patients with either CPHD (n = 35) or SOD (n = 68...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شاهد - دانشکده کشاورزی 1391

بیماری میوه سبز مرکبات توسط باکتری سخت کشت candidatus liberobacter asiaticus ایجاد می شود که اولین بار در چین توصیف شده است و در سال 1919 با نام رسمی huanglongbing معرفی گردید. این بیماری یکی از پرخسارت ترین بیماری های مرکبات درجنوب شرقی آسیا، شبه قاره هند، آفریقای جنوبی و شبه جزیره عربستان است. این بیماری در سال 1386 از جنوب ایران گزارش گردید. برای درک مکانیسم مولکولی برهمکنش میزبان-پاتوژن از ...

Journal: :Human reproduction 2017
C I Gonçalves F Fonseca T Borges F Cunha M C Lemos

STUDY QUESTION What is the prevalence and functional consequence of ANOS1 (KAL1) mutations in a group of men with congenital hypogonadotropic hypogonadism (CHH)? SUMMARY ANSWER Three of forty-two (7.1%) patients presented ANOS1 mutations, including a novel splice site mutation leading to exon skipping and a novel contiguous gene deletion associated with ichthyosis. WHAT IS KNOWN ALREADY CHH...

Journal: :iranian journal of basic medical sciences 0
lin liu department of hematology, the second affiliated hospital of kunming medical university, kunming 650101, china lin tan department of hematology, the first affiliated hospital of kunming medical university, kunming 650041, china zhenxin he department of hematology, the first affiliated hospital of kunming medical university, kunming 650041, china

objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...

Journal: :iranian red crescent medical journal 0
hamid alavi majd department of biostatistics, school of paramedical sciences, shahid beheshti university of medical sciences, tehran, ir iran atefeh talebi department of biostatistics, school of paramedial sciences, students’ research committee, shahid beheshti university of medical sciences, tehran, ir iran; department of biostatistics, school of paramedial sciences, students’ research committee, shahid beheshti university of medical sciences, tehran, ir iran. tel: +98-2122707347, fax: +98-2122721150 kambiz gilany reproductive biotechnology research center, avicenna research institute, acecr, tehran, ir iran nasibeh khayyer proteomics research center, shahid beheshti university of medical sciences, tehran, ir iran

conclusions some results of the correlation coefficients are not the same with visualization. the reason may be due to the small number of data. materials and methods in the foundation-application study, we constructed two-way gene networks using nonparametric methods, such as spearman’s rank correlation coefficient and blomqvist’s measure, and compared them with pearson’s correlation coefficie...

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