Screening newborns for treatable serious conditions is mandated in all US states and many other countries. After screening, Guthrie cards with residual blood (whole spots or portions of spots) are typically stored at ambient temperature in many facilities. The potential of archived dried blood spots (DBS) for at-birth molecular studies in epidemiological and clinical research is substantial. Ho...

Entire or partial deletions of the male-specific Y chromosome are associated with tumorigenesis, but whether any male-specific genes located on this chromosome play a tumor-suppressive role is unknown. Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also called KDM5D and SMCY), a male-specific protein, represses gene expression programs associated with cell invasiveness...

Let M be a compact simply connected hy-perkähler (or holomorphically symplectic) manifold, dim H 2 (M) = n. Assume that M is not a product of hyperkaehler manifolds. We prove that the Lie group so(n−3, 3) acts by automorphisms on the cohomology ring H * (M). Under this action, the space H 2 (M) is isomorphic to the fundamental representation of so(n − 3, 3). Let A r be the subring of H * (M) ge...

The crystal structure of the title compound, C(10)H(10)O(3), is characterized by classical intra-molecular hydrogen bonding. The hy-droxy group is disordered over two positions (77 and 23%). The crystal structure is stabilized via π-π [3.5986 (1) Å] and weak nonclassical C-H⋯O inter-actions [3.2797 (15) Å].

In the title compound, C(17)H(20)N(2)O(3), the amino N atom is in a planar environment (sum of angles = 360.0°). All hy-droxy H atoms are involved in hydrogen bonding. In the crystal structure, two O-H⋯O and an O-H⋯N(imino) hydrogen bond result in the formation of a three-dimensional network. The latter hydrogen bonding causes distortion of the planarity of the 4-HO-C(6)H(4)-CH=N-C(6)H(4)- frag...

hy do firms and inventors tend to locate in dense, costly areas? One intriguing hypothesis is that such geographic clustering lets them benefit from local knowledge spillovers. As nobel laureate robert Lucas has noted, the benefits of one person’s knowledge spilling over to others play a central role in economic growth and the existence of cities: “What can people be paying Manhattan or downtow...

In the title mol-ecule, C(18)H(13)N(3)O(4), the hy-droxy group is involved in the formation of an intra-molecular O-H⋯N hydrogen bond. The dihedral angle between the planes of the benzene ring and the naphthyl ring system is 9.0 (2)°. In the crystal, mol-ecules are linked through N-H⋯O hydrogen bonds into chains along the c axis.

In a previous report (Johnson & Donchin, 1978), we manipulated the discriminability of tone pairs that delivered feedback information in a time-estimation paradigm. As in other experiments using feedback stimuli, the event-related potentials elicited by these stimuli did not return to baseline in the 800-ms poststimulus interval. Since we were interested in this "Slow Wave" activity, the postst...

In the title compound, C(11)H(13)N(3)O(2), the 1,2,3-triazole ring and the phenol ring form a dihedral angle of 55.46 (5)°. In the crystal, inversion-related mol-ecules associate through pairs of hy-droxy-phenol O-H⋯O hydrogen bonds, giving centrosymmetric cyclic dimers [graph set R(2) (2)(18)]. These dimers are linked into infinite chains along [001], giving an overall two-dimensional network ...