Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients. Medical treatment is fraught with high recurrence rates mainly because of an incomplete understanding of the biological mechanisms that lead to keloids. The purpose of this project was to examine keloid pathogenesis from the epigenome perspective of DNA methylation. Geno...

Background: Although a number of hypotheses have been proposed for keloid pathogenesis, no single unifying hypothesis adequately explains its formation. For that reason, currently available therapies are palliative and have led to inconsistent results. The adipose tissue has been recognised as a reservoir of pro-inflammatory cytokines, which are directly involved in cell differentiation and pro...

Cyclin-dependent kinase 10 (CDK10) is a cell cycle regulating protein kinase, which has just been discriminated in recent years. In this paper, mRNA and protein expression of CDK10 were first investigated by a comparative study between 23 human keloid tissue samples and their adjacent normal skin. To further address its potential as a therapeutic target in the treatment of keloid, a plasmid exp...

BACKGROUND Keloid management can be difficult and frustrating, and the mechanisms underlying keloid formation are only partially understood. METHODS Using original and current literature in this field, this comprehensive review presents the major concepts of keloid pathogenesis and the treatment options stemming from them. RESULTS Mechanisms for keloid formation include alterations in growt...

Dear Sir, Keloids are thick, raised scars that represent an extreme form of abnormal scarring. Unlike normal scars, keloids extend beyond the original wound margin and rarely regress; instead, they tend to proliferate indefinitely.1-4 These bulky scars can significantly impair function due to itching, pain, and decreased range of motion5 and can negatively impact psychosocial well-being and ove...

Keloids are fibroproliferative disorders characterized by exuberant extracellular matrix deposition and transforming growth factor (TGF)-β/Smad pathway plays a pivotal role in keloid pathogenesis. Centella asiatica extract has been applied in scar management for ages. As one of its major components, asiatic acid (AA) has been recently reported to inhibit liver fibrosis by blocking TGF-β/Smad pa...

A keloid scar is an overgrowth of dense fibrous tissue that develops around a wound. These scars are raised scars that spread beyong the margins of the orinigal wound to normal skin by invasion. Keloid tissue consists of both an epithelium and dermal fibroblasts. Recent studies have primarily focused on keloid fibroblasts; however, the precise role of keratinocytes in the invasion process of ke...

OBJECTIVES Our goal was to investigate the relationship between keloid and telomerase as well as clarifying the influence of Wnt/β-catenin signaling on keloid cell proliferation. METHODS Tissues from 18 keloid patients were collected for further study. Keloid progenitor cells (KPC) and skin progenitor cells (SKP) were both included in this study. Lenti-virus transfection was used to divide ce...

Keloids are skin abnormalities that are characterized by excessive deposition of collagen bundles in the dermis. Patients with keloids complain not only about their cosmetic appearance, but also about continuous itching and/or tenderness associated with chronic inflammation. Degradation of extracellular matrix (ECM) may be upregulated, associated with the expansion of keloids into circumferenti...

K eloid scars—fibrous overgrowths that occur in sites of previous skin injury—are composed of excess collagen and often extend beyond the borders of the original wound (Figure 1). Keloids often develop soon after injury but can also occur up to several years following the initial traumatic insult. Common causes include surgical procedures, piercings, vaccinations, lacerations, and burn injuries...