نتایج جستجو برای: keratinization disorder
تعداد نتایج: 597575 فیلتر نتایج به سال:
The first born offspring of first-cousin parents was affected with a keratinization disorder thought to be nonbullous congenital ichthyosiform erythroderma (CIE). In each of three subsequent pregnancies, the parents elected to have prenatal diagnosis based on evaluation of fetal skin biopsies. The epidermis of fetus 1 was identical to normal 21-wk estimated gestation age (EGA) fetal epidermis, ...
Non-bullous congenital ichthyosiform erythroderma (NBCIE) is a hereditary disorder of keratinization caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte differentiation. Impaired function of these enzymes can cause pathologic epidermal scaling, significantly reduced skin barrier function. In this study, we have performed a focused, gen...
OBJECTIVE We aim to evaluate the effectiveness of the brush biopsy technique using OralCDx ® (OralScan Laboratories Inc., Suffern, NY) as a new method for early diagnosis and control of a "potentially malignant disorder" such as oral leukoplakia. DESIGN OF THE STUDY We performed a study in which samples were taken using OralCDx ® on 24 patients who visited the Master of Oral Medicine, Oral Su...
Porokeratotic eccrine ostial and dermal duct nevus with extensive linear distribution: a case report
Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is known as an uncommon disorder of keratinization in which acrosyringium is involved; however, its causes have yet remained unknown. It is presented clinically by discrete keratotic papules on distal extremities arranged in a linear pattern along Blaschko lines. Histopathologically, it is characterized by cornoid lamella, which is alm...
Olmsted syndrome (OS) is a rare congenital disorder characterized by palmoplantar and periorificial keratoderma, alopecia in most cases, and severe itching. The genetic basis for OS remained unidentified. Using whole-exome sequencing of case-parents trios, we have identified a de novo missense mutation in TRPV3 that produces p.Gly573Ser in an individual with OS. Nucleotide sequencing of five ad...
A simple culture technique is described for obtaining homogeneous populations of differentiating epidermal cells from adult amphibian skin. This population of cells continues its normal differentiation, namely keratinization, in vitro. By the third day of culture more than 99-9% of the cells in the population contain immunoreactive keratin. During the next 5-7 days of culture these cells synthe...
Trichilemmal cysts, also known as pilar cysts, are slow-growing lesions commonly found on the scalp of elderly women. They arise from outer root sheath epithelium and have a distinctive pattern of keratinization called trichilemmal keratinization. Here, we describe a rare case of a trichilemmal cyst on the lower lip mucosa of a 29-year-old man. The infrequency of intraoral hairs unquestionably ...
This study was carried out on the vaginal epithelium of eight Awassi ewes during estrus and luteal phases in order to evaluate the histological effect of vitamin A on the vaginal epithelium, vaginal smears were taken and stained by methylene blue. Light microscope was used in examination of slides. The present result revealed that vitamin A stimulated the process of keratinization which in turn...
Keratins are the characteristic structural proteins of the highly cornified epidermis of the skin, feathers, and hoof. Keratin proteins provide the structural basis for the unique properties of the biomaterial horn and its protective function against a wide range of environmental factors. Hoof horn is produced through a complex process of differentiation (keratinization) of epidermal cells. For...
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