Infections of the cornea can lead to corneal opacity and blindness if not identified quickly and managed appropriately. The terms infective keratitis, suppurative keratitis, and microbial keratitis are all used to describe suppurative infections of the cornea. These are characterised by the presence of white or yellowish infiltrates in the corneal stroma, with or without an overlaying corneal e...

ing improved outcomes. The result of longer healing times in fungal ulcers may be influenced by this. Re-epithelialization is a difficult endpoint tomeasure, particularly in fungal keratitis, so this result should be interpreted with some caution. Other factors associated with fungal and bacterial keratitis cases, such as geographic location of the patients, could act as confounders in this stu...

Thirty patients with bilateral herpetic keratitis were evaluated, 40% of whom were atopic. Stromal keratitis occurred in 40% of the eyes and recurrent ulceration in 68%. Four patients (5 eyes) developed secondary microbial keratitis. Visual acuity decreased to 6/60 or less because of corneal opacification in 17% of the eyes.

Infectious keratitis after penetrating keratoplasty (PK) is a devastating condition that may result in graft failure and poor visual outcome. In this study, we retrospectively reviewed the medical records of patients who underwent PK between 2009 and 2014, and recorded those who developed infectious keratitis. We compared the predisposing factors and organisms isolated to those identified in ou...

OBJECTIVE To evaluate the specific contact lens-related or other factors that may contribute to the outbreak of Fusarium keratitis. METHODS A case-control study was conducted of Fusarium keratitis in contact lens users in Singapore from March 1, 2005, to May 31, 2006, and included 61 patients with Fusarium keratitis and 188 population-based and 179 hospital-based control subjects. Interviewer...

Acanthamoeba keratitis is a type of protozoa keratitis caused by free-living fresh water Amoeba. It recently gains importance because of increasing incidence, difficulty in diagnosis and unsatisfactory treatment. It is seen more commonly in contact lens wear using homemade saline or may be in non-contact lens wearers due to swimming or bathing in contaminated water. This infection is commonly c...

Fungal keratitis is one of the leading cause of ocular morbidity. Fungal keratitis possesses a clinical challenge due to its slow pathologic process, overlapping features, diagnostic difficulty, and potential complications. Its increasing trend can be attributed to the use of contact lens, non-judiciary corticosteroid, and vegetative trauma. Early diagnosis and treatment is the cornerstone for ...

AIMS To report the clinical findings and visual outcome of patients with extended wear contact lens (EWCL) related bacterial keratitis. METHODS 11 cases with EWCL related bacterial keratitis were included. Corneal scrapings were obtained for cytology and cultures. RESULTS Nine patients had unilateral bacterial keratitis and two patients showed bilateral involvement. Corneal scrapings reveal...

The ocular surface is continuously exposed to potential pathogens, including free-living amoebae. Acanthamoeba species are among the most ubiquitous amoebae, yet Acanthamoeba keratitis is remarkably rare. The pathogenesis of Acanthamoeba keratitis is a complex, sequential process. Here we show that Acanthamoeba keratitis is profoundly affected by mannosylated proteins on the ocular surface, whi...

The use of contact lenses (CLs) has been widely associated with corneal alterations that range in symptomatology and severity. Lesions may vary from small peripheral sterile infiltrates to infectious central ulcers with sight-threatening potential. Contact lens wear has been described as the most important predisposing factor to microbial keratitis worldwide. Infections are more frequent in sof...