Case presentations describing a congenital variation of palmoplantar keratosis are presented. The majority of these conditions are autosomal dominant with associated nail dystrophy. A variant condition is described with little palmar keratosis; however, finger nail and toe nail dystrophy is the most common identifying feature. Gene identification and treatment protocol are presented. Fortunatel...

Cryotherapy is the most common treatment for actinic keratosis, but its effect is limited to individual lesions. Several topical drugs, however, are available that, in addition to treating individual actinic keratoses, target field cancerization and thereby act on subclinical lesions. Examples are 5-fluorouracil, imiquimod, diclofenac, and ingenol mebutate. We report on 17 patients with actinic...

Sir, Keratosis lichenoides chronica (KLC) is a rare and chronic skin disease characterized by erythemas, keratotic and lichenoid papules, arranged in a linear pattern (1) and seborrhoeic-like scaling lesions on the trunk and limbs (1, 2). The lesions are slowly progressive with no tendency to heal and are resistant to most therapeutic modalities. Typical locations are the limbs, face, nails, pa...

To investigate the function of trichohyalin during terminal differentiation of the skin, immunohistochemical studies were performed on trichohyalin and its related proteins, filaggrin and involucrin, the components of the cornified cell envelope. In skin disorders unrelated to tumours, weak trichohyalin expression was found in a few granular cells or in the horny layer of psoriasis, ichthyosis,...

A 64-year-old man was noted to have a single pigmented lesion in the nostril of his nose. Clinical examination revealed a 5 mm nodular growth and brown lesion. With a presumed clinical diagnosis of malignant skin tumor, a biopsy was performed. The histological examination revealed the unexpected diagnosis of pigmented inverted follicular keratosis. The inverted follicular keratosis is an uncomm...

This manuscript briefly describes an algorithm developed for the ISIC 2017 Skin Lesion Classification Competition. In this task, participants are asked to complete two independent binary image classification tasks that involve three unique diagnoses of skin lesions (melanoma, nevus, and seborrheic keratosis). In the first binary classification task, participants are asked to distinguish between...

We present a patient with partial monosomy of the short arm of chromosome 18 caused by de novo translocation t(Y;18) and a generalized form of keratosis pilaris (keratosis pilaris affecting the skin follicles of the trunk, limbs and face-ulerythema ophryogenes). Two-color FISH with centromere-specific Y and 18 DNA probes identified the derivative chromosome 18 as a dicentric with breakpoints in...

ADVICE: following a full submission fluorouracil 0.5% / salicylic acid 10% cutaneous solution (Actikerall®) is accepted for use within NHS Scotland. Indication under review: the topical treatment of slightly palpable and/or moderately thick hyperkeratotic actinic keratosis (grade I/II) in immunocompetent adult patients. Fluorouracil 0.5% / salicylic acid 10% cutaneous solution was superior to a...