A simple, sensitive and selective differential pulse voltammetry method for determination of paracetamol on a bare (unmodified) boron-doped diamond film electrode has been developed. It was found by cyclic voltammetry that paracetamol provided the quasireversible wave with oxidation peak on the forward scan about +0.90 V and smaller reduction peak on the reverse scan at +0.68 V vs. Ag/AgCl. The...

Background. Paracetamol poisoning is common all over the world, including in Russia. In 20–25% of cases, a massive dose drug observed: more than 30–40 g paracetamol at time.The aim study was to demonstrate efficacy using an increased doses acetylcysteine treatment admission.Results. Patient G., 22 years old, took 70 tablets (35 g) for suicide 3 hours before admission hospital. The blood level 4...

Sir, Codeine phosphate is a popular drug of abuse and is commonly taken in preparations combined with either aspirin or paracetamol. Preparations containing larger amounts of codeine (30 mg) are especially popular. Opiate tolerance may result in dependent individuals needing to ingest large amounts of these drugs, thus risking potentially fatal paracetamol or aspirin toxicity. A 37-year-old wom...

The mechanical and disintegration properties of paracetamol tablets formulated using Delonix regia seed gum (DRSG) as a binder have been studied in this work. Acacia BP (ACG) and tragacanth BP (TRG) were used as official gum standards. The mechanical properties, i.e. tensile strength (TS) and brittle fracture index (BFI), showed that with an increase in concentration of the gum binder, the tens...

In this study a 3D printed capsule designed to break from the physiological pressures in antropyloric region was evaluated for its ability deliver synthetic octapeptide octreotide beagle dogs when co-formulated with permeation enhancer sodium caprate. The pressure sensitive capsules were compared traditional enteric coated hard gelatin and tablets. Paracetamol, which is completely absorbed dogs...

The first HPLC method was developed for the simultaneous determination of paracetamol (PC), ascorbic acid (AA), and pseudoephedrine HCl (PE) in their co-formulated tablets. Separation was achieved on a C18 column in 5 min using a mobile phase composed of methanol-0.05 M phosphate buffer (35:65, v/v) at pH 2.5 with UV detection at 220 nm. Linear calibration curves were constructed over concentra...

This study was undertaken to explore gum from Bombax buonopozense calyxes as a binding agent in formulation of immediate release dosage forms using wet granulation method. The granules were characterized to assess the flow and compression properties and when compressed, non-compendial and compendial tests were undertaken to assess the tablet properties for tablets prepared with bombax gum in co...

The applicability of Raman imaging for pharmaceutics production ranges from the characterization pharmaceutical formulations, kinetic processes in drug delivery to rapid detection and identification counterfeit drugs/contaminants. Acetaminophen (Paracetamol, APAP) is an analgesic antipyretic one most consumed medicines worldwide. On other hand, compound 4-aminophenol (4-AP) a hydrolytic product...

Introduction: To investigate the dosing accuracy using split tablets in paediatric patients. Methods: Five brands of tablets (Alvedon® (paracetamol), Catapresan® (clonidine), Hydrocortone® (hydrocortisone), Prednisolon® (prednisolon) and Tavegyl® (clemastine) were split into halves and quarters by hand or by using a tablet splitter. The resulting halves and quarters were weighed. Results: Three...