INTRODUCTION Recombinant human erythropoietin (EPO) is known to provide organ protection against ischemia-reperfusion injury through its pleiotropic properties. The aim of this single-site, randomized, case-controlled, and double-blind study was to investigate the effect of pre-emptive EPO administration on the incidence of postoperative acute kidney injury (AKI) in patients with risk factors f...

The diagnosis of acute kidney injury (AKI) is usually based on changes in serum creatinine, but such measurements are a poor marker of acute deterioration in kidney function. We performed a systematic review of publications that evaluated the accuracy and reliability of serum and urinary biomarkers in human subjects when used for the diagnosis of established AKI or early AKI, or to risk stratif...

Renal dysfunction has become a validated prognostic factor indicating increased morbidity and mortality in different cardiovascular diseases, such as acute coronary syndrome or chronic heart failure. Impaired kidney function may not only reflect chronic renal disease but also deterioration secondary to haemodynamic disturbances, as decreased cardiac output and elevated central venous pressure m...

BACKGROUND The renoprotective effect of N-acetylcystein in patients undergoing coronary artery bypass graft surgery is controversial. METHODS We assessed the renoprotective effect of the highest dose of N-acetylcystein sanctioned for clinical use in a prospective, double-blind, placebo-controlled study including 70 chronic kidney disease patients, stage 3 or 4, who underwent coronary artery b...

Introduction There is a controversy regarding accuracy of neutrophil gelatinase-associated lipocalin (NGAL) and Cystatin C in early detection of acute kidney injury (AKI). The present study aimed to compare the diagnostic value of two biomarkers in this regard. Method In the present diagnostic accuracy study, all children between the ages of 1 month to 14 years were entered. Pediatric Risk, I...

The results of published studies modern biomarkers used in the diagnosis acute kidney injury (AKI) were summarized. search was carried out PubMed/MEDLINE, Scopus, eLibrary databases. AKI occurs 10–15% all inpatients and 50% intensive care patients, affects economic aspects treatment rehabilitation. literature review allowed to draw conclusions about significant advantage new (cystatin C, neutro...

Paecilomyces sinclairiis (PS) is known as a functional food or human health supplement. However concerns have been raised about its kidney toxicity. This study was performed to investigate the kidney toxicity of PS by 13 week-oral administration to rats. Blood urea nitrogen (BUN), serum creatinine, and kidney damage biomarkers including beta-2-microglobulin (β2m), glutathione S-transferase alph...

Objective: To find out the effect of Dexmedetomidine infusion on renal function in patients undergoing Coronary Artery Bypass Graft (CABG) surgery.
 Study Design: Randomized control trial (RCT- NCT05375188).
 Place and Duration Study: The research was conducted Department Anesthesia, National Institute Cardiovascular Diseases Karachi Pakistan, from Jun to Sep 2021.
 Methodology: ...

INTRODUCTION Serum creatinine is a 'gold standard' criterion of recognizing and staging of acute kidney injury (AKI) despite it being a suboptimal, delayed indicator. The interpretation of increased values of biomarkers imposes great difficulty regarding cardiac surgery procedures performed with cardiopulmonary bypass and may lead to under- or overestimated diagnosis. The aim of this study was ...